Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | FGF23 | Q9GZV9 | 1/20 | 0.40 |
| ▸ | P4HB | P07237 | 4/20 | 0.40 |
| ▸ | FBP1 | P09467 | 1/20 | 0.38 |
| ▸ | TTK | P33981 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA3 | P07451 | 1/20 | 0.37 |
| ▸ | CA6 | P23280 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6273971 | 1.00 | ALDH1A1 (0.50) | ALDH1A1MAPTKDM4ENPC1GLA | |
| SCHEMBL4711008 | 0.80 | KDM4E (0.53) | ALDH1A1MAPTKDM4ENPC1GLA | |
| SCHEMBL4711006 | 0.80 | KDM4E (0.53) | ALDH1A1MAPTKDM4ENPC1GLA | |
| SCHEMBL13771875 | 0.74 | CYP1A2 (0.50) | NPC1FGF23CA12CA2CA6 | |
| SCHEMBL9000547 | 0.74 | MMP2 (0.47) | ALDH1A1MAPTKDM4ENPC1LMNA | |
| SCHEMBL710053 | 0.73 | NPC1 (0.57) | ALDH1A1MAPTKDM4ENPC1GLA | |
| SCHEMBL1307576 | 0.73 | NPC1 (0.57) | ALDH1A1MAPTKDM4ENPC1GLA | |
| SCHEMBL8699093 | 0.73 | FBP1 (0.59) | ALDH1A1MAPTKDM4ELMNAL3MBTL1 | |
| SCHEMBL1687898 | 0.73 | FBP1 (0.59) | ALDH1A1MAPTKDM4ELMNAL3MBTL1 | |
| SCHEMBL21574805 | 0.73 | FBP1 (0.59) | ALDH1A1MAPTKDM4ELMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005116010-A1 | EP4 RECEPTOR AGONIST, COMPOSITIONS AND METHODS THEREOF | MERCK FROSST CANADA LTD. (CA) | 2005-12-08 | — | — | WO | disclosed |