Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 3/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.41 |
| ▸ | RXRA | P19793 | 3/20 | 0.41 |
| ▸ | RXRB | P28702 | 3/20 | 0.41 |
| ▸ | RXRG | P48443 | 2/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.41 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.41 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.40 |
| ▸ | THRA | P10827 | 3/20 | 0.40 |
| ▸ | THRB | P10828 | 3/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6275841 | 0.91 | NR4A2 (0.55) | NR4A2MRGPRX4RXRARXRBRXRG | |
| SCHEMBL6275567 | 0.89 | MAOA (0.44) | NR4A2MRGPRX4RXRARXRBRXRG | |
| SCHEMBL6279313 | 0.88 | THRA (0.52) | NR4A2MRGPRX4RXRARXRBRXRG | |
| SCHEMBL6275961 | 0.88 | KDM5A (0.40) | NR4A2MRGPRX4RXRARXRBRXRG | |
| SCHEMBL6275621 | 0.87 | NR4A2 (0.41) | NR4A2MRGPRX4RXRARXRBRXRG | |
| SCHEMBL6274687 | 0.87 | MRGPRX4 (0.51) | NR4A2MRGPRX4RXRARXRBRXRG | |
| SCHEMBL6268755 | 0.87 | THRA (0.46) | NR4A2MRGPRX4RXRARXRBRXRG | |
| SCHEMBL6273400 | 0.87 | THRA (0.51) | NR4A2MRGPRX4RXRARXRBRXRG | |
| SCHEMBL6272586 | 0.86 | PTGER1 (0.45) | NR4A2KDM5AKDM4CKDM5B | |
| SCHEMBL6274608 | 0.86 | NR4A2 (0.46) | NR4A2MRGPRX4RXRARXRBKDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005116010-A1 | EP4 RECEPTOR AGONIST, COMPOSITIONS AND METHODS THEREOF | MERCK FROSST CANADA LTD. (CA) | 2005-12-08 | — | — | WO | claimed |