Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 3/20 | 0.52 |
| ▸ | THRB | P10828 | 3/20 | 0.52 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.49 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.49 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.49 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.49 |
| ▸ | RXRA | P19793 | 4/20 | 0.49 |
| ▸ | RXRB | P28702 | 4/20 | 0.49 |
| ▸ | RXRG | P48443 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.47 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6273400 | 0.99 | THRA (0.51) | THRATHRBPTGER1PTGER4PTGER3 | |
| SCHEMBL6275606 | 0.91 | THRA (0.56) | THRATHRBRXRARXRBRXRG | |
| SCHEMBL6273976 | 0.90 | THRA (0.49) | THRATHRBHPGDTSHRSMN1; SMN2 | |
| SCHEMBL6273397 | 0.90 | PTGER1 (0.49) | THRATHRBPTGER1PTGER4PTGER3 | |
| SCHEMBL6275841 | 0.89 | NR4A2 (0.55) | THRATHRBPTGER4PTGER2RXRA | |
| SCHEMBL6275455 | 0.89 | THRA (0.57) | THRATHRBRXRARXRBRXRG | |
| SCHEMBL6275582 | 0.89 | THRA (0.47) | THRATHRBPTGER1PTGER4PTGER3 | |
| SCHEMBL6275621 | 0.88 | NR4A2 (0.41) | THRATHRBPTGER1PTGER4PTGER3 | |
| SCHEMBL6275567 | 0.88 | MAOA (0.44) | THRATHRBRXRARXRBRXRG | |
| SCHEMBL6274199 | 0.88 | NR4A2 (0.41) | THRATHRBPTGER4PTGER2RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170143733-A1 | COMPOUNDS AND METHODS FOR SKIN REPAIR | ALLERGAN, INC. | 2017-05-25 | — | — | US | disclosed |
| US-20170143733-A1 | COMPOUNDS AND METHODS FOR SKIN REPAIR | ALLERGAN, INC. | 2017-05-25 | — | — | US | disclosed |
| US-20140142092-A1 | COMPOUNDS AND METHODS FOR SKIN REPAIR | ALLERGAN, INC. (US) | 2014-05-22 | — | — | US | disclosed |
| US-20140142092-A1 | COMPOUNDS AND METHODS FOR SKIN REPAIR | ALLERGAN, INC. (US) | 2014-05-22 | — | — | US | disclosed |
| WO-2005116010-A1 | EP4 RECEPTOR AGONIST, COMPOSITIONS AND METHODS THEREOF | MERCK FROSST CANADA LTD. (CA) | 2005-12-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140142092-A1 | COMPOUNDS AND METHODS FOR SKIN REPAIR | PTGER4, PTGER2, PTGER1 | THRA 3100/4885THRB 2250/4885PTGER1 3/4885 |
| US-20170143733-A1 | COMPOUNDS AND METHODS FOR SKIN REPAIR | PTGER4, PTGER2, PTGER1 | THRA 3100/4885THRB 2250/4885PTGER1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.