Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | MITF | O75030 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | XDH | P47989 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.49 |
| ▸ | TOP1 | P11387 | 1/20 | 0.47 |
| ▸ | TOP2A | P11388 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | TDP2 | O95551 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | CASP9 | P55211 | 1/20 | 0.45 |
| ▸ | CASP6 | P55212 | 1/20 | 0.45 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6275444 | 1.00 | ALDH1A1 (0.58) | ALDH1A1MAPTSMN1; SMN2MITFLMNA | |
| SCHEMBL11268807 | 0.80 | XDH (0.62) | ALDH1A1MAPTSMN1; SMN2MITFLMNA | |
| SCHEMBL27515150 | 0.79 | SOS1 (0.68) | ALDH1A1MAPTSMN1; SMN2MITFLMNA | |
| SCHEMBL30428710 | 0.75 | MEN1 (0.55) | ALDH1A1SMN1; SMN2LMNAKMT2ANPSR1 | |
| SCHEMBL1078524 | 0.74 | TOP1 (0.66) | ALDH1A1SMN1; SMN2LMNAKMT2ANPSR1 | |
| SCHEMBL3745130 | 0.72 | RPS6KA3 (0.71) | MAPTXDHTDP1TDP2CASP7 | |
| SCHEMBL8324118 | 0.71 | XDH (0.52) | ALDH1A1MAPTSMN1; SMN2MITFLMNA | |
| SCHEMBL5198970 | 0.71 | BAX (0.47) | ALDH1A1MAPTSMN1; SMN2MITFLMNA | |
| SCHEMBL10730964 | 0.69 | MAPT (0.56) | ALDH1A1MAPTSMN1; SMN2MITFLMNA | |
| SCHEMBL30019907 | 0.69 | XDH (0.78) | ALDH1A1MAPTMITFHTTXDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6855726-B1 | Quinolones as serine protease inhibitors | WARNER-LAMBERT COMPANY LLC (US) | 2005-02-15 | — | — | US | disclosed |
| EP-1091955-A1 | QUINOLONES AS SERINE PROTEASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2001-04-18 | — | — | EP | disclosed |
| WO-1999050263-A1 | QUINOLONES AS SERINE PROTEASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1999-10-07 | — | — | WO | disclosed |