Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.71 |
| ▸ | ABL1 | P00519 | 2/20 | 0.71 |
| ▸ | LCK | P06239 | 2/20 | 0.71 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.71 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.71 |
| ▸ | KDR | P35968 | 2/20 | 0.71 |
| ▸ | GSK3B | P49841 | 2/20 | 0.71 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.71 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.71 |
| ▸ | LYN | P07948 | 1/20 | 0.71 |
| ▸ | MET | P08581 | 1/20 | 0.71 |
| ▸ | KIT | P10721 | 1/20 | 0.71 |
| ▸ | PIM1 | P11309 | 1/20 | 0.71 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.71 |
| ▸ | SRC | P12931 | 1/20 | 0.71 |
| ▸ | PRKCA | P17252 | 1/20 | 0.71 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.71 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.71 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.71 |
| ▸ | AKT1 | P31749 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5695446 | 0.80 | MAPT (0.59) | RPS6KA3ABL1LCKPDGFRBPDGFRA | |
| SCHEMBL5695396 | 0.80 | MAPT (0.59) | RPS6KA3ABL1LCKPDGFRBPDGFRA | |
| SCHEMBL30019907 | 0.79 | XDH (0.78) | RPS6KA3ABL1LCKPDGFRBPDGFRA | |
| SCHEMBL5481833 | 0.79 | NPC1 (0.68) | RPS6KA3ABL1LCKPDGFRBPDGFRA | |
| SCHEMBL5481832 | 0.79 | NPC1 (0.68) | RPS6KA3ABL1LCKPDGFRBPDGFRA | |
| SCHEMBL1394809 | 0.79 | APP (0.64) | RPS6KA3ABL1LCKPDGFRBPDGFRA | |
| SCHEMBL1394810 | 0.79 | APP (0.64) | RPS6KA3ABL1LCKPDGFRBPDGFRA | |
| SCHEMBL11268807 | 0.79 | XDH (0.62) | RPS6KA3ABL1LCKPDGFRBPDGFRA | |
| SCHEMBL27515150 | 0.78 | SOS1 (0.68) | XDHMAPTTDP1TDP2CASP7 | |
| SCHEMBL14521054 | 0.78 | XDH (0.52) | RPS6KA3ABL1LCKPDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090264494-A1 | USE OF NEUROPROTECTIVE 3-SUBSTITUTED INDOLONE COMPOSITIONS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2009-10-22 | — | — | US | claimed |
| US-20100298376-A1 | USE OF NOVEL NEUROPROTECTIVE 3-SUBSTITUTED INDOLONE COMPOSITIONS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2010-11-25 | — | — | US | disclosed |
| US-20090264494-A1 | USE OF NEUROPROTECTIVE 3-SUBSTITUTED INDOLONE COMPOSITIONS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2009-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298376-A1 | USE OF NOVEL NEUROPROTECTIVE 3-SUBSTITUTED INDOLONE COMPOSITIONS | NLN, HTT, PARK7 | RPS6KA3 1532/4885ABL1 3058/4885LCK 2866/4885 |
| US-20090264494-A1 | USE OF NEUROPROTECTIVE 3-SUBSTITUTED INDOLONE COMPOSITIONS | NLN, BDNF, HTT | RPS6KA3 940/4885ABL1 2143/4885LCK 2309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.