Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM5 | Q9NZQ8 | 3/20 | 0.39 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.36 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.33 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.33 |
| ▸ | PYGL | P06737 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8408800 | 0.87 | HTR2C (0.41) | TRPM5TRPM4HTR2CSRD5A1SRD5A2 | |
| SCHEMBL7986945 | 0.79 | PDE5A (0.38) | HTR2CALDH1A1KDM4EHPGDMEN1 | |
| SCHEMBL8406851 | 0.76 | MAPK1 (0.42) | ALDH1A1KDM4EHPGDHTTMEN1 | |
| SCHEMBL8407009 | 0.75 | SRD5A1 (0.43) | HTR2CSRD5A1SRD5A2PYGL | |
| SCHEMBL11895740 | 0.74 | PYGL (0.46) | TRPM5TRPM4HTR2CSRD5A1SRD5A2 | |
| SCHEMBL10875369 | 0.73 | ALDH1A1 (0.42) | TRPM5TRPM4HTR2CSRD5A1SRD5A2 | |
| SCHEMBL8408755 | 0.72 | CHRNB2 (0.40) | — | |
| SCHEMBL30667064 | 0.71 | HTR2C (0.44) | TRPM5TRPM4HTR2CSRD5A1AADAT | |
| SCHEMBL5902128 | 0.71 | HTR2C (0.44) | TRPM5TRPM4HTR2CSRD5A1AADAT | |
| SCHEMBL30831622 | 0.71 | HTR2C (0.44) | TRPM5TRPM4HTR2CSRD5A1AADAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6916838-B1 | 1-benzylpyrazole-3-carboxylic acid tricyclic derivatives as cannabinoid receptor antagonists | SANOFI-AVENTIS (FR) | 2005-07-12 | — | — | US | disclosed |