Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.33 |
| ▸ | HTR3A | P46098 | 6/20 | 0.33 |
| ▸ | HTR3B | O95264 | 3/20 | 0.33 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.33 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.33 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5492690 | 0.81 | KDM4E (0.30) | ALDH1A1KDM4EMAPTGFER | |
| SCHEMBL3469383 | 0.79 | ALDH1A1 (0.31) | ALDH1A1 | |
| SCHEMBL6276533 | 0.76 | LMNA (0.36) | ALDH1A1ADRA2CKDM4EMAPTKMT2A | |
| SCHEMBL18756387 | 0.73 | ADRA2C (0.35) | ALDH1A1ADRA2CKDM4EGAAMAPT | |
| SCHEMBL23220858 | 0.71 | ADRA2C (0.36) | ALDH1A1ADRA2CKDM4EGAAMAPT | |
| SCHEMBL29745137 | 0.68 | CHKA (0.39) | ALDH1A1ADRA2CKDM4EGAAMAPT | |
| SCHEMBL4715172 | 0.68 | ADRA2C (0.34) | ALDH1A1ADRA2CKDM4EGAAMAPT | |
| SCHEMBL468785 | 0.68 | ADRA2C (0.34) | ALDH1A1ADRA2CKDM4EGAAMAPT | |
| SCHEMBL17748900 | 0.65 | QDPR (0.35) | — | |
| SCHEMBL22415701 | 0.65 | HTR3A (0.33) | ALDH1A1ADRA2CKDM4EGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430013-A1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | Amgen, Inc (US) | 2012-03-21 | — | — | EP | claimed |
| WO-2010132598-A1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | AMGEN INC. (US) | 2010-11-18 | — | — | WO | claimed |
| EP-2231602-A1 | GAMMA SECRETASE MODULATORS | Amgen, Inc (US) | 2010-09-29 | — | — | EP | claimed |
| WO-2009075874-A1 | GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-06-18 | — | — | WO | claimed |
| EP-2231602-A1 | GAMMA SECRETASE MODULATORS | Amgen, Inc (US) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009075874-A1 | GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-06-18 | — | — | WO | disclosed |