Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.63 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | CDC7 | O00311 | 2/20 | 0.42 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6280962 | 0.88 | PTGS2 (0.48) | PTGS2MAPK14CDC7DBF4KDM4E | |
| SCHEMBL6280968 | 0.85 | PTGS2 (0.51) | PTGS2MAPK14KDM4EALOX5 | |
| SCHEMBL6276676 | 0.83 | PTGS2 (0.64) | PTGS2MAPK14CDC7DBF4KDM4E | |
| SCHEMBL6285570 | 0.83 | MAPK14 (0.54) | PTGS2MAPK14CDC7DBF4 | |
| SCHEMBL6501123 | 0.82 | PTGS2 (0.67) | PTGS2MAPK14CDC7DBF4KDM4E | |
| SCHEMBL6276678 | 0.82 | PTGS2 (0.62) | PTGS2MAPK14KDM4EARMAPK10 | |
| SCHEMBL6285603 | 0.82 | MAPK14 (0.50) | PTGS2MAPK14CDC7DBF4KDM4E | |
| SCHEMBL6282345 | 0.81 | PTGS2 (0.68) | PTGS2MAPK14CDC7DBF4MAPK10 | |
| SCHEMBL19864308 | 0.80 | PTGS2 (0.63) | PTGS2MAPK14KDM4EARMAPK10 | |
| SCHEMBL19864303 | 0.80 | PTGS2 (0.63) | PTGS2MAPK14KDM4EARMAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1205478-A1 | p38MAP KINASE INHIBITORS | Takeda Chemical Industries, Ltd. (JP) | 2002-05-15 | — | — | EP | claimed |
| US-6962933-B1 | Method for inhibiting p38 MAP kinase or TNF-α production using a 1,3-thiazole | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-11-08 | — | — | US | disclosed |
| EP-1205478-A1 | p38MAP KINASE INHIBITORS | Takeda Chemical Industries, Ltd. (JP) | 2002-05-15 | — | — | EP | disclosed |