Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 3/20 | 0.40 |
| ▸ | DBF4 | Q9UBU7 | 3/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | TSPO | P30536 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6285603 | 0.87 | MAPK14 (0.50) | MAPK14PTGS2CDC7DBF4IDO1 | |
| SCHEMBL6508320 | 0.84 | MAPK14 (0.55) | MAPK14PTGS2ADORA3ADORA1ADORA2A | |
| SCHEMBL6283249 | 0.84 | MAPK14 (0.54) | MAPK14PTGS2ADORA3ADORA1ADORA2A | |
| SCHEMBL6280968 | 0.83 | PTGS2 (0.51) | MAPK14PTGS2 | |
| SCHEMBL6280962 | 0.83 | PTGS2 (0.48) | MAPK14PTGS2CDC7DBF4IDO1 | |
| SCHEMBL6276579 | 0.83 | PTGS2 (0.63) | MAPK14PTGS2CDC7DBF4 | |
| SCHEMBL6283253 | 0.83 | MAPK14 (0.53) | MAPK14PTGS2ADORA3ADORA1ADORA2A | |
| SCHEMBL6280438 | 0.81 | MAPK14 (0.59) | MAPK14PTGS2ADORA3ADORA1ADORA2A | |
| SCHEMBL6504016 | 0.80 | MAPK14 (0.81) | MAPK14PTGS2ADORA3 | |
| SCHEMBL6504993 | 0.79 | MAPK14 (0.54) | MAPK14PTGS2ADORA3ADORA1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1205478-A1 | p38MAP KINASE INHIBITORS | Takeda Chemical Industries, Ltd. (JP) | 2002-05-15 | — | — | EP | claimed |
| US-6962933-B1 | Method for inhibiting p38 MAP kinase or TNF-α production using a 1,3-thiazole | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-11-08 | — | — | US | disclosed |
| EP-1205478-A1 | p38MAP KINASE INHIBITORS | Takeda Chemical Industries, Ltd. (JP) | 2002-05-15 | — | — | EP | disclosed |