Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7844066 | 0.87 | PTGS2 (0.59) | PTGS2ALOX5PTGDR2KDM4EALDH1A1 | |
| SCHEMBL6280962 | 0.85 | PTGS2 (0.48) | PTGS2ALOX5PTGDR2KDM4EALDH1A1 | |
| SCHEMBL6276579 | 0.85 | PTGS2 (0.63) | PTGS2ALOX5KDM4EMAPK14 | |
| SCHEMBL6498802 | 0.84 | PTGS2 (0.52) | PTGS2ALOX5PTGDR2KDM4EALDH1A1 | |
| SCHEMBL6285570 | 0.83 | MAPK14 (0.54) | PTGS2MAPK14 | |
| SCHEMBL6285603 | 0.82 | MAPK14 (0.50) | PTGS2KDM4EALDH1A1MAPTMAPK14 | |
| SCHEMBL6282411 | 0.81 | PTGS2 (0.57) | PTGS2ALOX5PTGDR2KDM4EALDH1A1 | |
| SCHEMBL11455410 | 0.80 | PTGS2 (0.66) | PTGS2ALOX5PTGDR2KDM4EALDH1A1 | |
| SCHEMBL7843526 | 0.80 | PTGS2 (0.78) | PTGS2ALOX5MAPK14 | |
| SCHEMBL6503358 | 0.80 | PTGS2 (0.78) | PTGS2ALOX5MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1205478-A1 | p38MAP KINASE INHIBITORS | Takeda Chemical Industries, Ltd. (JP) | 2002-05-15 | — | — | EP | claimed |
| US-6962933-B1 | Method for inhibiting p38 MAP kinase or TNF-α production using a 1,3-thiazole | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-11-08 | — | — | US | disclosed |
| EP-1205478-A1 | p38MAP KINASE INHIBITORS | Takeda Chemical Industries, Ltd. (JP) | 2002-05-15 | — | — | EP | disclosed |