Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | HTR7 | P34969 | 2/20 | 0.35 |
| ▸ | HTR6 | P50406 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4796860 | 1.00 | DRD2 (0.35) | DRD2HTR7HTR6HTR2ALMNA | |
| SCHEMBL14081882 | 0.83 | DRD2 (0.33) | DRD2HTR7HTR6HTR2A | |
| Hydrochloric Acid SCHEMBL4803329 | 0.82 | DRD2 (0.33) | DRD2HTR7HTR6HTR2A | |
| SCHEMBL4804163 | 0.76 | SMN1; SMN2 (0.46) | LMNAMAPT | |
| SCHEMBL8925965 | 0.70 | DRD2 (0.39) | DRD2HTR7HTR6HTR2AMAPT | |
| SCHEMBL5154968 | 0.68 | LMNA (0.44) | LMNAMAPT | |
| SCHEMBL5165760 | 0.67 | DRD2 (0.42) | DRD2HTR7HTR6HTR2AMAPT | |
| SCHEMBL10359367 | 0.67 | TSHR (0.38) | DRD2HTR7HTR6HTR2AMAPT | |
| SCHEMBL6689590 | 0.67 | LMNA (0.43) | LMNAMAPT | |
| SCHEMBL2827397 | 0.66 | MAPT (0.42) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1587782-A1 | 3-ARYLOXY/THIO-3-SUBSTITUTED PROPANAMINES AND THEIR USE IN INHIBITING SEROTONIN AND NOREPINEPHRINE REUPTAKE | Eli Lilly and Company (US) | 2005-10-26 | — | — | EP | disclosed |
| WO-2004043904-A1 | 3-ARYLOXY/THIO-3-SUBSTITUTED PROPANAMINES AND THEIR USE IN INHIBITING SEROTONIN AND NOREPHINEPHRINE REUPTAKE | ELI LILLY AND COMPANY (US) | 2004-05-27 | — | — | WO | disclosed |