Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 5/20 | 0.38 |
| ▸ | FYN | P06241 | 6/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | JAK1 | P23458 | 4/20 | 0.34 |
| ▸ | JAK3 | P52333 | 4/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.34 |
| ▸ | CD38 | P28907 | 2/20 | 0.34 |
| ▸ | TTK | P33981 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | HPGDS | O60760 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL626162 | 0.79 | CD38 (0.34) | PIM1KCNH2CD38HPGDS | |
| SCHEMBL627850 | 0.79 | JAK1 (0.35) | PIM1FYNKCNH2JAK1JAK3 | |
| SCHEMBL627849 | 0.77 | FYN (0.46) | PIM1FYNKCNH2JAK1JAK3 | |
| SCHEMBL626163 | 0.74 | HSD11B1 (0.32) | JAK1JAK3IRAK4 | |
| SCHEMBL625636 | 0.69 | MAP3K12 (0.44) | — | |
| SCHEMBL2250791 | 0.66 | MKNK1 (0.53) | PIM1FYNTTK | |
| SCHEMBL12494024 | 0.63 | IRAK4 (0.43) | PIM1JAK1JAK3PIM2TTK | |
| SCHEMBL2252121 | 0.61 | MKNK1 (0.53) | FYNTTK | |
| SCHEMBL24765705 | 0.60 | TTK (0.47) | PIM1JAK1JAK3PIM2TTK | |
| SCHEMBL25783428 | 0.60 | TTK (0.47) | PIM1JAK1JAK3PIM2TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |