Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD38 | P28907 | 2/20 | 0.34 |
| ▸ | PIM1 | P11309 | 2/20 | 0.32 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.32 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.32 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.32 |
| ▸ | GPX4 | P36969 | 2/20 | 0.31 |
| ▸ | HPGDS | O60760 | 2/20 | 0.31 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.30 |
| ▸ | VNN1 | O95497 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL625008 | 0.79 | PIM1 (0.35) | PIM1BMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL628002 | 0.79 | PIM1 (0.38) | CD38PIM1HPGDSKCNH2 | |
| SCHEMBL626163 | 0.71 | HSD11B1 (0.32) | — | |
| SCHEMBL625280 | 0.68 | PIK3CA (0.49) | PIM1BMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL2588468 | 0.63 | OPRM1 (0.61) | — | |
| SCHEMBL2250791 | 0.61 | MKNK1 (0.53) | PIM1 | |
| SCHEMBL24919667 | 0.60 | KCNH2 (0.39) | KCNH2 | |
| SCHEMBL18111942 | 0.60 | KCNH2 (0.39) | KCNH2 | |
| SCHEMBL20940105 | 0.60 | KCNH2 (0.39) | KCNH2 | |
| SCHEMBL627849 | 0.59 | FYN (0.46) | PIM1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |