Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K12 | Q12852 | 17/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.43 |
| ▸ | DLK1 | P80370 | 1/20 | 0.42 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL627440 | 0.87 | FYN (0.45) | MAP3K12PIK3CADLK1 | |
| SCHEMBL625468 | 0.87 | MAP3K12 (0.42) | MAP3K12PIK3CADLK1 | |
| SCHEMBL627397 | 0.86 | PIK3CA (0.49) | MAP3K12PIK3CADLK1 | |
| SCHEMBL625236 | 0.85 | MAP3K12 (0.45) | MAP3K12PIK3CADLK1 | |
| SCHEMBL624428 | 0.85 | MAP3K12 (0.47) | MAP3K12PIK3CADLK1 | |
| SCHEMBL625301 | 0.85 | MAP3K12 (0.44) | MAP3K12PIK3CADLK1 | |
| SCHEMBL625635 | 0.84 | PIK3CA (0.51) | PIK3CA | |
| SCHEMBL625282 | 0.83 | MAP3K12 (0.45) | MAP3K12PIK3CADLK1 | |
| SCHEMBL626207 | 0.83 | MAP3K12 (0.46) | MAP3K12PIK3CA | |
| SCHEMBL626892 | 0.82 | PIK3CA (0.42) | MAP3K12PIK3CADLK1MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |