Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 8/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 8/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.38 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 2/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.36 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6279750 | 0.87 | GRIN1 (0.39) | GRIN1GRIN2BGRM1 | |
| SCHEMBL6285997 | 0.81 | GRM1 (0.40) | GRIN1GRIN2BGABRA1GABRG2GABRB3 | |
| SCHEMBL6284962 | 0.77 | MIF (0.35) | GRIN1GRIN2BCYP11B2GRM1 | |
| SCHEMBL6283855 | 0.74 | GABRA1 (0.44) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL6284455 | 0.69 | GABRA1 (0.56) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL2651076 | 0.69 | CYP3A4 (0.54) | CYP2A6CYP2C19CYP11B2CYP11B1ABL1 | |
| SCHEMBL30445600 | 0.66 | CYP2A6 (0.49) | CYP2E1CYP2A6CYP2C9CYP2B6CYP2C19 | |
| SCHEMBL30577111 | 0.65 | CYP2A6 (0.60) | CYP2E1CYP2A6CYP2C9CYP2B6CYP2C19 | |
| SCHEMBL27249454 | 0.65 | CYP17A1 (0.47) | CYP2E1CYP2A6CYP2C9CYP2B6CYP2C19 | |
| SCHEMBL2665898 | 0.64 | CYP2A6 (0.51) | GABRA1GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6887885-B2 | Imidazo[4,5-c]pyridin-4-one analogues as GABAA receptor ligands | MERCK SHARP & DOHME LTD | 2005-05-03 | — | — | US | claimed |
| US-6887885-B2 | Imidazo[4,5-c]pyridin-4-one analogues as GABAA receptor ligands | MERCK SHARP & DOHME LTD | 2005-05-03 | — | — | US | disclosed |
| US-20040132767-A1 | Imidazo[4,5-c]pyridin-4-one analogues as GABAA receptor ligands | MERCK SHARP & DOHME LTD. (GB) | 2004-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040132767-A1 | Imidazo[4,5-c]pyridin-4-one analogues as GABAA receptor ligands | GABRA1, GABRA2, GABRA3 | CTSD 4752/4885BACE1 866/4885BACE2 1485/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.