Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.51 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27691816 | 0.85 | ALB (0.45) | MAPTALDH1A1KMT2AMEN1L3MBTL1 | |
| SCHEMBL152680 | 0.83 | MAPT (0.70) | DDB1CRBNCYP2C9CYP2C19MAPT | |
| SCHEMBL5251522 | 0.83 | MAPT (0.70) | DDB1CRBNCYP2C9CYP2C19MAPT | |
| SCHEMBL12939967 | 0.83 | SMN1; SMN2 (0.62) | MAPTPOLBALDH1A1KMT2AMEN1 | |
| SCHEMBL11052179 | 0.83 | ALDH1A1 (0.50) | CYP2C9CYP2C19MAPTPOLBALDH1A1 | |
| SCHEMBL11048294 | 0.83 | ALDH1A1 (0.50) | CYP2C9CYP2C19MAPTPOLBALDH1A1 | |
| SCHEMBL11052192 | 0.81 | KMT2A (0.59) | DDB1CRBNCYP2C9CYP2C19POLB | |
| SCHEMBL5474552 | 0.80 | PARP1 (0.49) | DDB1CRBNCYP2C9CYP2C19MAPT | |
| SCHEMBL30046922 | 0.80 | CYP11B1 (0.50) | SMN1; SMN2DHPS | |
| SCHEMBL10700291 | 0.80 | MAPK1 (0.48) | POLBALDH1A1KMT2AMEN1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005113573-A2 | METHOD OF SUPPORT-BASED CHEMICAL SYNTHESIS | MIXTURE SCIENCES, INC. (US) | 2005-12-01 | — | — | WO | disclosed |
| US-20050261474-A1 | Method of support-based chemical synthesis | MIXTURE SCIENCES, INC. | 2005-11-24 | — | — | US | disclosed |
| US-20050112693-A1 | Diketodiazacyclic compounds, diazacyclic compounds and combinatorial libraries thereof | NEFZI ADEL (US) | 2005-05-26 | — | — | US | disclosed |
| US-6809202-B2 | SYNTHETIC PEPTIDES | TORREY PINES INSTITUTE FOR MOLECULAR STUDIES | 2004-10-26 | — | — | US | disclosed |
| US-20030120066-A1 | Synthetic peptides | NEFZI ADEL (US) | 2003-06-26 | — | — | US | disclosed |
| US-6534506-B2 | For therapy of cancer, neurofibromin benign proliferative disorder; blindness related to retinal vascularization; infections from hepatitis delta and related viruses; prophylaxis of restenosis; polycystic kidney disease | MERCK & CO., INC. | 2003-03-18 | — | — | US | disclosed |
| EP-1181279-A4 | DIKETODIAZACYCLIC COMPOUNDS, DIAZACYCLIC COMPOUNDS AND COMBINATORIAL LIBRARIES THEREOF | TORREY PINES INST (US) | 2002-09-25 | — | — | EP | disclosed |
| US-20020123497-A1 | Inhibitors of prenyl-protein transferase | MERCK SHARP & DOHME CORP. | 2002-09-05 | — | — | US | disclosed |
| US-6441172-B1 | DI- AND TRI-SUBSTITUTED-1,4-DIAZACYCLIC COMPOUNDS | TORREY PINES INSTITUTE FOR MOLECULAR STUDIES | 2002-08-27 | — | — | US | disclosed |
| EP-1181279-A1 | DIKETODIAZACYCLIC COMPOUNDS, DIAZACYCLIC COMPOUNDS AND COMBINATORIAL LIBRARIES THEREOF | TORREY PINES INSTITUTE FOR MOLECULAR STUDIES (US) | 2002-02-27 | — | — | EP | disclosed |
| WO-2001077116-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2001-10-18 | — | — | WO | disclosed |
| WO-2000069830-A1 | DIKETODIAZACYCLIC COMPOUNDS, DIAZACYCLIC COMPOUNDS AND COMBINATORIAL LIBRARIES THEREOF | TORREY PINES INSTITUTE FOR MOLECULAR STUDIES (US) | 2000-11-23 | — | — | WO | disclosed |
| US-4139621-A | TRANQUILIZERS | BEECHAM GROUP LIMITED (GB) | 1979-02-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020123497-A1 | Inhibitors of prenyl-protein transferase | FNTA, KRAS, NRAS | DDB1 173/4885CRBN 733/4885CYP2C9 3644/4885 |
| US-20050112693-A1 | Diketodiazacyclic compounds, diazacyclic compounds and combinatorial libraries thereof | DHPS, DCK, DAZAP1 | DDB1 416/4885CRBN 463/4885CYP2C9 1703/4885 |
| US-20050261474-A1 | Method of support-based chemical synthesis | CYP2F1, CYP4F3, CYP4F2 | DDB1 2581/4885CRBN 1764/4885CYP2C9 209/4885 |
| US-20030120066-A1 | Synthetic peptides | VIP, NGLY1, GRPR | DDB1 445/4885CRBN 666/4885CYP2C9 4706/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.