Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 1/20 | 0.47 |
| ▸ | STAT1 | P42224 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | TOP1 | P11387 | 3/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.32 |
| ▸ | PTGES | O14684 | 1/20 | 0.32 |
| ▸ | CYCS | P99999 | 3/20 | 0.31 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.30 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.30 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17112278 | 0.86 | STAT3 (0.55) | STAT3STAT1FFAR1TOP1CYCS | |
| SCHEMBL19407291 | 0.80 | STAT3 (0.74) | STAT3STAT1TOP1PTGESCYCS | |
| Acetic Acid SCHEMBL29181913 | 0.78 | STAT3 (0.33) | STAT3STAT1 | |
| SCHEMBL9764318 | 0.77 | STAT3 (0.58) | STAT3STAT1PTGES | |
| SCHEMBL5013624 | 0.77 | STAT3 (0.57) | STAT3STAT1TOP1CYCSENPP2 | |
| SCHEMBL17112277 | 0.75 | STAT3 (0.39) | STAT3STAT1JAK2TYK2DGAT1 | |
| SCHEMBL9641446 | 0.75 | STAT3 (0.44) | STAT3STAT1ENPP2 | |
| Acetic Acid SCHEMBL21121213 | 0.75 | STAT3 (0.33) | STAT3STAT1 | |
| Acetic Acid SCHEMBL28646520 | 0.75 | STAT3 (0.33) | STAT3STAT1 | |
| Acetic Acid SCHEMBL28633839 | 0.75 | STAT3 (0.33) | STAT3STAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6953868-B2 | Oxyfunctionalization of polyolefins | DOW GLOBAL TECHNOLOGIES INC. (US) | 2005-10-11 | — | — | US | claimed |
| US-20040249086-A1 | Oxyfunctionalization of polyolefins | REGENTS OF THE UNIVERSITY OF MINNESOTA | 2004-12-09 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040249086-A1 | Oxyfunctionalization of polyolefins | PPOX, PPIF, ETFA | STAT3 2942/4885STAT1 2908/4885FFAR1 4386/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.