Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | ZDHHC7 | Q9NXF8 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.40 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.40 |
| ▸ | FDPS | P14324 | 4/20 | 0.38 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | LAP3 | P28838 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7341648 | 0.98 | ZDHHC7 (0.44) | OPRM1ZDHHC7TP53LCKPPARD | |
| SCHEMBL4839978 | 0.98 | ZDHHC7 (0.44) | OPRM1ZDHHC7TP53LCKPPARD | |
| SCHEMBL7332033 | 0.98 | ZDHHC7 (0.44) | OPRM1ZDHHC7TP53LCKPPARD | |
| SCHEMBL7336733 | 0.98 | ZDHHC7 (0.44) | OPRM1ZDHHC7TP53LCKPPARD | |
| SCHEMBL7337998 | 0.98 | ZDHHC7 (0.44) | OPRM1ZDHHC7TP53LCKPPARD | |
| SCHEMBL7335577 | 0.98 | ZDHHC7 (0.44) | OPRM1ZDHHC7TP53LCKPPARD | |
| SCHEMBL628572 | 0.92 | — | — | |
| SCHEMBL2670779 | 0.85 | DNM1 (0.45) | OPRM1ZDHHC7LCKPPARDZDHHC20 | |
| SCHEMBL2670949 | 0.85 | ZDHHC7 (0.41) | OPRM1ZDHHC7LCKPPARDZDHHC20 | |
| SCHEMBL2671272 | 0.85 | ZDHHC7 (0.41) | OPRM1ZDHHC7TP53LCKPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107072993-B | Pharmaceutical containing sodium-dependent phosphate transporter inhibitor | 中外制药株式会社 | 2021-02-12 | — | — | CN | disclosed |
| WO-2020071470-A1 | PHTHALOCYANINE COMPOUND AND USE THEREOF | 山本化成株式会社 | 2020-04-09 | — | — | WO | disclosed |
| US-20180319798-A1 | 1,3,4,8-Tetrahydro-2H-Pyrido[1,2-a]Pyrazine Derivative and Use of the Same as HIV Integrase Inhibitor | JAPAN TOBACCO INC. (JP) | 2018-11-08 | — | — | US | disclosed |
| US-10087178-B2 | Substituted spiropyrido[1,2-a]pyrazine derivative and medicinal use thereof as HIV integrase inhibitor | JAPAN TOBACCO INC. (JP) | 2018-10-02 | — | — | US | disclosed |
| US-10065950-B2 | Substituted thiazoles as HIV integrase inhibitors | JAPAN TOBACCO INC. (JP) | 2018-09-04 | — | — | US | disclosed |
| EP-2940019-B1 | SUBSTITUTED SPIROPYRIDO[1,2-a]PYRAZINE DERIVATIVE AND MEDICINAL USE THEREOF AS HIV INTEGRASE INHIBITOR | JAPAN TOBACCO INC (JP) | 2018-03-28 | — | — | EP | disclosed |
| US-20170044156-A1 | SUBSTITUTED SPIROPYRIDO[1,2-a]PYRAZINE DERIVATIVE AND MEDICINAL USE THEREOF AS HIV INTEGRASE INHIBITOR | JAPAN TOBACCO INC. (JP) | 2017-02-16 | — | — | US | disclosed |
| US-20160046641-A1 | SUBSTITUTED SPIROPYRIDO[1,2-a]PYRAZINE DERIVATIVE AND PHARMACEUTICAL USE OF SAME AS HIV INTEGRASE INHIBITOR | JAPAN TOBACCO INC (JP) | 2016-02-18 | — | — | US | disclosed |
| EP-2940019-A1 | SUBSTITUTED SPIROPYRIDO[1,2-a]PYRAZINE DERIVATIVE AND MEDICINAL USE THEREOF AS HIV INTEGRASE INHIBITOR | Japan Tobacco, Inc. (JP) | 2015-11-04 | — | — | EP | disclosed |
| EP-2540720-B1 | 1,3,4,8-TETRAHYDRO-2H-PYRIDO[1,2-A]PYRAZINE DERIVATIVE AND USE OF SAME AS HIV INTEGRASE INHIBITOR | JAPAN TOBACCO INC (JP) | 2015-04-15 | — | — | EP | disclosed |
| EP-1200390-A1 | PRODUCTION OF N-SUBSTITUTED 2,7-DIALKYL-4-HYDROXY-5-AMINO-8-ARYL-OCTANOYLAMIDES | Speedel Pharma AG (CH) | 2002-05-02 | — | — | EP | disclosed |
| EP-1180038-A2 | ANTIFUNGAL COMBINATION USE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-02-20 | — | — | EP | disclosed |
| WO-2002008172-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED OCTANOYL AMIDES | SPEEDEL PHARMA AG (CH) | 2002-01-31 | — | — | WO | disclosed |
| WO-2002002508-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED OCTANOYL AMIDES | SPEEDEL PHARMA AG (CH) | 2002-01-10 | — | — | WO | disclosed |
| WO-2002002500-A1 | PREPARATION OF (R)-2-ALKYL-3-PHENYLPROPIONIC ACIDS | SPEEDEL PHARMA AG (CH) | 2002-01-10 | — | — | WO | disclosed |
| WO-2002002487-A1 | PROCESS FOR THE PREPARATION OF (R)-2-ALKYL-3-PHENYL-1-PROPANOLS | SPEEDEL PHARMA AG (CH) | 2002-01-10 | — | — | WO | disclosed |
| WO-2001009083-A1 | PRODUCTION OF N-SUBSTITUTED 2,7-DIALKYL-4-HYDROXY-5-AMINO-8-ARYL-OCTANOYLAMIDES | SPEEDEL PHARMA AG (CH) | 2001-02-08 | — | — | WO | disclosed |
| US-6174887-B1 | Amide compounds and use of the same | JAPAN TOBACCO INC. (JP) | 2001-01-16 | — | — | US | disclosed |
| WO-2000072865-A2 | ANTIFUNGAL COMBINATION USE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-12-07 | — | — | WO | disclosed |
| EP-0849256-A1 | AMIDE COMPOUNDS AND USE OF THE SAME | Japan Tobacco Inc. (JP) | 1998-06-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180319798-A1 | 1,3,4,8-Tetrahydro-2H-Pyrido[1,2-a]Pyrazine Derivative and Use of the Same as HIV Integrase Inhibitor | IMPA1, IMPDH1, TYMP | OPRM1 3617/4885ZDHHC7 2571/4885TP53 454/4885 |
| US-10065950-B2 | Substituted thiazoles as HIV integrase inhibitors | TYMP, TYMS, IMPDH1 | OPRM1 4068/4885ZDHHC7 2371/4885TP53 449/4885 |
| US-10087178-B2 | Substituted spiropyrido[1,2-a]pyrazine derivative and medicinal use thereof as HIV integrase inhibitor | IMPDH1, IMPDH2, SAV1 | OPRM1 3042/4885ZDHHC7 4127/4885TP53 1091/4885 |
| US-20160046641-A1 | SUBSTITUTED SPIROPYRIDO[1,2-a]PYRAZINE DERIVATIVE AND PHARMACEUTICAL USE OF SAME AS HIV INTEGRASE INHIBITOR | IMPDH1, IMPDH2, IMPA1 | OPRM1 3332/4885ZDHHC7 4292/4885TP53 932/4885 |
| US-20170044156-A1 | SUBSTITUTED SPIROPYRIDO[1,2-a]PYRAZINE DERIVATIVE AND MEDICINAL USE THEREOF AS HIV INTEGRASE INHIBITOR | IMPDH1, IMPDH2, SAV1 | OPRM1 3042/4885ZDHHC7 4127/4885TP53 1091/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.