Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | THPO | P40225 | 1/20 | 0.52 |
| ▸ | MTOR | P42345 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6284560 | 0.81 | NPC1 (0.56) | NPC1RAB9AALDH1A1SMN1; SMN2GAA | |
| SCHEMBL10144116 | 0.77 | ALDH1A1 (0.60) | NPC1RAB9AALDH1A1SMN1; SMN2GAA | |
| SCHEMBL8197608 | 0.74 | RAB9A (0.56) | NPC1RAB9AALDH1A1SMN1; SMN2NFKB1 | |
| SCHEMBL6281340 | 0.74 | NPC1 (0.57) | NPC1RAB9AALDH1A1SMN1; SMN2GAA | |
| SCHEMBL6284442 | 0.74 | NPC1 (0.57) | NPC1RAB9AALDH1A1SMN1; SMN2GAA | |
| SCHEMBL6959411 | 0.74 | ALDH1A1 (0.52) | NPC1RAB9AALDH1A1SMN1; SMN2GAA | |
| SCHEMBL6963854 | 0.72 | RAB9A (0.48) | NPC1RAB9AALDH1A1SMN1; SMN2GAA | |
| SCHEMBL6965126 | 0.72 | RAB9A (0.48) | NPC1RAB9AALDH1A1SMN1; SMN2GAA | |
| SCHEMBL6287452 | 0.72 | ALDH1A1 (0.42) | NPC1RAB9AALDH1A1SMN1; SMN2GAA | |
| SCHEMBL6959508 | 0.71 | HPGD (0.49) | NPC1RAB9AALDH1A1SMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6960606-B2 | Adamantyl Thiazole Thioureas | PARKER HUGHES INSTITUTE (US) | 2005-11-01 | — | — | US | disclosed |
| US-20030207921-A1 | Aromatic and heterocyclic thiazolyl thiourea compounds and use | PARKER HUGHES INSTITUTE (US) | 2003-11-06 | — | — | US | disclosed |
| EP-1326852-A1 | AROMATIC AND HETEROCYCLIC THIAZOLYL THIOUREA COMPOUNDS AND USE | Parker Hughes Institute (US) | 2003-07-16 | — | — | EP | disclosed |
| EP-1194427-B1 | THIOPHENE-ETHYL THIOUREA COMPOUNDS AND USE IN THE TREATMENT OF HIV | PARKER HUGHES INST (US) | 2003-03-05 | — | — | EP | disclosed |
| WO-2002032889-A1 | AROMATIC AND HETEROCYCLIC THIAZOLYL THIOUREA COMPOUNDS AND USE | PARKER HUGHES INSTITUTE (US) | 2002-04-25 | — | — | WO | disclosed |
| EP-1194427-A1 | THIOPHENE-ETHYL THIOUREA COMPOUNDS AND USE IN THE TREATMENT OF HIV | Parker Hughes Institute (US) | 2002-04-10 | — | — | EP | disclosed |
| WO-2000078755-A1 | THIOPHENE-ETHYL THIOUREA COMPOUNDS AND USE IN THE TREATMENT OF HIV | PARKER HUGHES INSTITUTE (US) | 2000-12-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030207921-A1 | Aromatic and heterocyclic thiazolyl thiourea compounds and use | TYMP, PNP, TPMT | NPC1 985/4885RAB9A 2750/4885ALDH1A1 2972/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.