Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.57 |
| ▸ | RAB9A | P51151 | 5/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | THPO | P40225 | 1/20 | 0.57 |
| ▸ | MTOR | P42345 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6284560 | 0.76 | NPC1 (0.56) | NPC1RAB9ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL6284442 | 0.74 | NPC1 (0.57) | NPC1RAB9ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL6281076 | 0.74 | NPC1 (0.52) | NPC1RAB9ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL1321656 | 0.73 | ALDH1A1 (1.00) | NPC1RAB9ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL31060951 | 0.73 | ALDH1A1 (0.60) | NPC1RAB9ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL8687284 | 0.73 | RAB9A (0.58) | NPC1RAB9ALMNASMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL4249912 | 0.72 | ALDH1A1 (0.97) | NPC1RAB9ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL6952333 | 0.72 | PKM (0.57) | NPC1RAB9ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL6952330 | 0.72 | PKM (0.57) | NPC1RAB9ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL6963164 | 0.71 | NPC1 (0.56) | NPC1RAB9ALMNASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6960606-B2 | Adamantyl Thiazole Thioureas | PARKER HUGHES INSTITUTE (US) | 2005-11-01 | — | — | US | disclosed |
| US-20030207921-A1 | Aromatic and heterocyclic thiazolyl thiourea compounds and use | PARKER HUGHES INSTITUTE (US) | 2003-11-06 | — | — | US | disclosed |
| EP-1326852-A1 | AROMATIC AND HETEROCYCLIC THIAZOLYL THIOUREA COMPOUNDS AND USE | Parker Hughes Institute (US) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002032889-A1 | AROMATIC AND HETEROCYCLIC THIAZOLYL THIOUREA COMPOUNDS AND USE | PARKER HUGHES INSTITUTE (US) | 2002-04-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030207921-A1 | Aromatic and heterocyclic thiazolyl thiourea compounds and use | TYMP, PNP, TPMT | NPC1 985/4885RAB9A 2750/4885LMNA 4721/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.