Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 2/20 | 0.50 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.50 |
| ▸ | FYN | P06241 | 1/20 | 0.50 |
| ▸ | CHUK | O15111 | 1/20 | 0.50 |
| ▸ | INSR | P06213 | 1/20 | 0.50 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2967361 | 0.85 | MAPK8 (0.58) | MAPK8CAMKK2FYNCHUKINSR | |
| SCHEMBL9540301 | 0.76 | IKBKB (0.46) | RAB9ASMN1; SMN2L3MBTL1ALDH1A1PARP1 | |
| Hydrochloric Acid SCHEMBL26632024 | 0.75 | MKNK1 (0.46) | CHUKMKNK1MKNK2SMN1; SMN2CA1 | |
| SCHEMBL21246919 | 0.73 | PTPRC (0.51) | RAB9AL3MBTL1ALDH1A1PTPRCPTPN1 | |
| SCHEMBL6634531 | 0.72 | CA12 (0.55) | SMN1; SMN2L3MBTL1ALDH1A1POLBCA1 | |
| SCHEMBL28264223 | 0.72 | MKNK1 (0.61) | CAMKK2MKNK1MKNK2RAB9AL3MBTL1 | |
| SCHEMBL1222758 | 0.71 | RXRA (0.58) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL12189290 | 0.71 | L3MBTL1 (0.60) | SMN1; SMN2L3MBTL1ALDH1A1PTPRCPTPN1 | |
| SCHEMBL3898826 | 0.71 | MKNK1 (0.57) | CAMKK2MKNK1MKNK2L3MBTL1CHEK2 | |
| SCHEMBL2950525 | 0.71 | MKNK1 (0.60) | MKNK1MKNK2RAB9AL3MBTL1CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1608616-A1 | BIPHENYL CARBOXYLIC AMIDE P38 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-12-28 | — | — | EP | disclosed |
| WO-2004089874-A1 | BIPHENYL CARBOXYLIC AMIDE P38 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-10-21 | — | — | WO | disclosed |