Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 11/20 | 0.46 |
| ▸ | HTR1A | P08908 | 4/20 | 0.46 |
| ▸ | DRD2 | P14416 | 4/20 | 0.46 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | GCK | P35557 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6276945 | 0.83 | MAOB (0.38) | ABCB1HTR1ADRD2MAOBFLT1 | |
| SCHEMBL8406776 | 0.77 | ABCB1 (0.55) | ABCB1HTR1ADRD2 | |
| SCHEMBL6272143 | 0.77 | MRGPRX4 (0.53) | ABCB1HTR1ADRD2SMN1; SMN2 | |
| SCHEMBL6275728 | 0.76 | KMT2A (0.51) | ABCB1HTR1ADRD2GCKMAPT | |
| SCHEMBL6279347 | 0.75 | ABCB1 (0.40) | ABCB1HTR1ADRD2MAOBSLC6A4 | |
| SCHEMBL6277051 | 0.75 | ABCB1 (0.34) | ABCB1KDR | |
| SCHEMBL6281809 | 0.74 | ABCB1 (0.34) | ABCB1MAPT | |
| SCHEMBL6281472 | 0.74 | ABCB1 (0.33) | ABCB1 | |
| SCHEMBL8408170 | 0.71 | HTR1A (0.61) | ABCB1HTR1ADRD2 | |
| SCHEMBL8320664 | 0.71 | HTR1A (0.61) | ABCB1HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005116010-A1 | EP4 RECEPTOR AGONIST, COMPOSITIONS AND METHODS THEREOF | MERCK FROSST CANADA LTD. (CA) | 2005-12-08 | — | — | WO | claimed |