Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | RGS12 | O14924 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4774509 | 0.79 | DPP4 (0.45) | LMNASLC6A4TSHRCYP2D6HTR2A | |
| SCHEMBL3454932 | 0.76 | TAAR1 (0.38) | LMNAADRA2CKDM4EADRA2AHIF1A | |
| SCHEMBL8681720 | 0.76 | SRC (0.46) | LMNAKDM4EHIF1AALDH1A1CYP3A4 | |
| SCHEMBL5596091 | 0.71 | LMNA (0.42) | LMNAADRA2CKDM4EADRA2AHIF1A | |
| Phenyl Ethanol SCHEMBL8075664 | 0.71 | LMNA (0.56) | LMNAADRA2CKDM4EADRA2AHIF1A | |
| Phenyl Ethanol SCHEMBL32685157 | 0.71 | — | — | |
| Phenyl Ethanol SCHEMBL27653400 | 0.71 | LMNA (0.56) | LMNAADRA2CKDM4EADRA2AHIF1A | |
| Phenyl Ethanol SCHEMBL7144 | 0.71 | — | — | |
| Phenyl Ethanol SCHEMBL2164 | 0.71 | — | — | |
| Phenyl Ethanol SCHEMBL2165 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6870039-B2 | Synthesis of oligonucleotides | ISIS PHARMACEUTICALS, INC. (US) | 2005-03-22 | — | — | US | disclosed |
| US-20040063925-A1 | Synthesis of oligonucleotides | ISIS PHARMACEUTICALS, INC. | 2004-04-01 | — | — | US | disclosed |
| US-6646114-B2 | Especially phosphorothioate oligonucleotides, and to intermediates used in that process; solution phase synthesis having improved efficiencies and enhanced convenience and cost | ISIS PHARMACEUTICALS, INC. | 2003-11-11 | — | — | US | disclosed |
| US-20030069412-A1 | Synthesis of oligonucleotides | RAVIKUMAR VASULINGA (US) | 2003-04-10 | — | — | US | disclosed |
| US-6486312-B2 | LIQUID PHASE BIOSYNTHESIS | ISIS PHARMACEUTICALS, INC. | 2002-11-26 | — | — | US | disclosed |
| US-6294664-B1 | PREPARING OLIGONUCLEOTIDE BLOCKS HAVING COMMON SUBSEQUENCES, PHOSPITYLATING, AND PERFORMING SOLID PHASE SYNTHESIS (SPS) TO FORM TARGET OLIGONUCLEOTIDES WHEREIN THE SYNTHONS USED IN SPS COMPRISE PHOSPHITYLATED OLIGONUCLEOTIDE BLOCKS | ISIS PHARMACEUTICALS, INC. | 2001-09-25 | — | — | US | disclosed |
| US-20010018510-A1 | Synthesis of oligonucleotides | ISIS PHARMACEUTICALS, INC. | 2001-08-30 | — | — | US | disclosed |
| US-6211350-B1 | REACTING SYNTHON WITH TWO NUCLEOSIDE UNITS AND WITH SYNTHON HAVING ONE NUCLEOSIDE UNIT TO OBTAIN OLIGONUCLEOTIDE CONTAINING PHOSPHOROTHIOATE GROUPS | ISIS PHARMACEUTICALS, INC. | 2001-04-03 | — | — | US | disclosed |
| US-6124450-A | Processes and intermediates for phosphorous-containing covalent linkages | ISIS PHARMACEUTICALS, INC. (US) | 2000-09-26 | — | — | US | disclosed |
| US-6001982-A | Synthesis of oligonucleotides | ISIS PHARMACEUTICALS, INC. (US) | 1999-12-14 | — | — | US | disclosed |
| EP-0766688-A4 | SYNTHESIS OF OLIGONUCLEOTIDES | ISIS PHARMACEUTICALS INC (US) | 1998-12-30 | — | — | EP | disclosed |
| US-5847106-A | Monomeric and dimeric nucleosides with silyl-containing diamino phosphorous linkages | ISIS PHARMACEUTICALS INC. (US) | 1998-12-08 | — | — | US | disclosed |
| EP-0766688-A1 | SYNTHESIS OF OLIGONUCLEOTIDES | ISIS PHARMACEUTICALS, INC. (US) | 1997-04-09 | — | — | EP | disclosed |
| US-5614621-A | Process for preparing oligonucleotides using silyl-containing diamino phosphorous reagents | ISIS PHARMACEUTICALS, INC. (US) | 1997-03-25 | — | — | US | disclosed |
| US-5571902-A | OLIGOMERIZATION IN THE PRESENCE OF TETRAZOLE COMPOUNDS | ISIS PHARMACEUTICALS, INC. (US) | 1996-11-05 | — | — | US | disclosed |
| EP-0711301-A4 | PROCESSES AND INTERMEDIATES FOR PHOSPHOROUS-CONTAINING COVALENT LINKAGES | ISIS PHARMACEUTICALS INC (US) | 1996-07-17 | — | — | EP | disclosed |
| EP-0711301-A1 | PROCESSES AND INTERMEDIATES FOR PHOSPHOROUS-CONTAINING COVALENT LINKAGES | ISIS PHARMACEUTICALS, INC. (US) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995032980-A1 | SYNTHESIS OF OLIGONUCLEOTIDES | ISIS PHARMACEUTICALS, INC. (US) | 1995-12-07 | — | — | WO | disclosed |
| WO-1995004065-A1 | PROCESSES AND INTERMEDIATES FOR PHOSPHOROUS-CONTAINING COVALENT LINKAGES | ISIS PHARMACEUTICALS, INC. (US) | 1995-02-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063925-A1 | Synthesis of oligonucleotides | RNGTT, POLRMT, POLI | LMNA 1993/4885ADRA2C 4573/4885KDM4E 3995/4885 |
| US-20030069412-A1 | Synthesis of oligonucleotides | RNGTT, POLRMT, POLI | LMNA 1993/4885ADRA2C 4573/4885KDM4E 3995/4885 |
| US-20010018510-A1 | Synthesis of oligonucleotides | RNGTT, POLRMT, POLI | LMNA 1993/4885ADRA2C 4573/4885KDM4E 3995/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.