Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.30 |
| ▸ | TTK | P33981 | 1/20 | 0.30 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6281660 | 1.00 | CSNK1A1 (0.33) | CSNK1A1TYRO3DYRK1BROCK2SCN9A | |
| SCHEMBL6281665 | 0.87 | NPC1 (0.30) | — | |
| SCHEMBL5879199 | 0.74 | KDR (0.43) | — | |
| SCHEMBL5787346 | 0.74 | KDR (0.43) | — | |
| SCHEMBL7501148 | 0.61 | GPR52 (0.43) | CSNK1A1TYRO3DYRK1BALDH1A1LMNA | |
| SCHEMBL7501158 | 0.61 | GPR52 (0.43) | CSNK1A1TYRO3DYRK1BALDH1A1LMNA | |
| SCHEMBL20518208 | 0.60 | NFE2L2 (0.45) | LMNANPSR1SMN1; SMN2 | |
| SCHEMBL4529566 | 0.59 | CSNK1A1 (0.54) | CSNK1A1TYRO3DYRK1BALDH1A1LMNA | |
| SCHEMBL5249631 | 0.58 | KDR (0.47) | — | |
| SCHEMBL2855495 | 0.58 | KDM4E (0.55) | ALDH1A1NPSR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6891044-B2 | Indazole compounds and pharmaceutical compositions for Inhibiting protein kinases, and methods for their use | AGOURON PHARMACEUTICALS, INC. (US) | 2005-05-10 | — | — | US | disclosed |