Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.56 |
| ▸ | P2RY1 | P47900 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6278439 | 0.84 | PTGDR2 (0.55) | PTGDR2P2RY1LMNASMN1; SMN2 | |
| SCHEMBL27641494 | 0.79 | PTGDR2 (0.69) | PTGDR2LMNASMN1; SMN2 | |
| SCHEMBL4128277 | 0.78 | PTGDR2 (0.74) | PTGDR2MEN1KMT2A | |
| SCHEMBL4128021 | 0.78 | LMNA (0.77) | PTGDR2P2RY1LMNASMN1; SMN2 | |
| SCHEMBL5504172 | 0.77 | PTGDR2 (0.56) | PTGDR2P2RY1LMNASMN1; SMN2 | |
| SCHEMBL4123301 | 0.77 | PTGDR2 (0.59) | PTGDR2P2RY1LMNASMN1; SMN2 | |
| SCHEMBL4123305 | 0.77 | PTGDR2 (0.59) | PTGDR2P2RY1LMNASMN1; SMN2 | |
| SCHEMBL5503246 | 0.77 | PTGDR2 (0.59) | PTGDR2P2RY1LMNASMN1; SMN2 | |
| SCHEMBL4127033 | 0.77 | PTGDR2 (0.56) | PTGDR2P2RY1LMNASMN1; SMN2 | |
| SCHEMBL4123938 | 0.77 | PTGDR2 (0.63) | PTGDR2LMNASMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1556047-A2 | PGD2 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-07-27 | — | — | EP | disclosed |
| WO-2004032848-A2 | PGD2 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2004-04-22 | — | — | WO | disclosed |