Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 8/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | LIPC | P11150 | 1/20 | 0.45 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6280 | 1.00 | STAT3 (0.54) | STAT3MEN1KMT2AMAPK1MAPT | |
| SCHEMBL7207 | 0.92 | STAT3 (0.45) | STAT3MEN1KMT2AMAPK1MAPT | |
| SCHEMBL7209 | 0.92 | STAT3 (0.45) | STAT3MEN1KMT2AMAPK1MAPT | |
| SCHEMBL11909530 | 0.90 | STAT3 (0.56) | STAT3MEN1KMT2AMAPK1MAPT | |
| SCHEMBL11909527 | 0.90 | STAT3 (0.56) | STAT3MEN1KMT2AMAPK1MAPT | |
| SCHEMBL5904 | 0.87 | NPY5R (0.42) | STAT3KMT2AMAPK1MAPT | |
| SCHEMBL5906 | 0.87 | NPY5R (0.42) | STAT3KMT2AMAPK1MAPT | |
| SCHEMBL6261 | 0.85 | KAT2B (0.44) | MEN1KMT2AMAPTRAB9AHTT | |
| SCHEMBL6263 | 0.85 | KAT2B (0.44) | MEN1KMT2AMAPTRAB9AHTT | |
| SCHEMBL12076494 | 0.84 | LIPC (0.48) | MEN1KMT2AMAPTLIPCLIPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493310-A1 | BENZIMIDAZOLES AS FATTY ACID SYNTHASE INHIBITORS | GlaxoSmithKline LLC (US) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011056635-A1 | BENZIMIDAZOLES AS FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2011-05-12 | — | — | WO | disclosed |