SCHEMBL6282292

SCHEMBL6282292

Cc1cc([C]=O)cc(C)c1O

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 1/20 0.50
CA2 P00918 1/20 0.50
CYP2C9 P11712 2/20 0.40
CYP3A4 P08684 2/20 0.40
CYP1A2 P05177 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2B6 P20813 1/20 0.40
ESR1 P03372 1/20 0.39
ESR2 Q92731 1/20 0.39
KDM4E B2RXH2 3/20 0.38
MAPT P10636 3/20 0.38
MEN1 O00255 3/20 0.38
KMT2A Q03164 3/20 0.38
USP2 O75604 1/20 0.38
ALDH1A1 P00352 3/20 0.38
EEF2K O00418 1/20 0.38
SRC P12931 1/20 0.38
TTR P02766 4/20 0.37
GAA P10253 2/20 0.36
LMNA P02545 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9122486 0.81 CYP2C9 (0.57) CA1CA2CYP2C9CYP3A4CYP1A2
SCHEMBL12620797 0.78 CA1 (0.55) CA1CA2CYP2C9CYP3A4CYP1A2
SCHEMBL1312596 0.78 CYP3A4 (0.32) CYP3A4TRPA1
SCHEMBL2807287 0.74 CA1 (0.50) CA1CA2CYP2C9CYP3A4CYP1A2
SCHEMBL197918 0.74 TTR (0.58) CA1CA2CYP2C9CYP3A4CYP1A2
SCHEMBL132438 0.72 KDM4E (0.42) CA1CA2CYP2C9CYP3A4KDM4E
SCHEMBL7664968 0.70 ALDH1A1 (0.40) CYP3A4ALDH1A1ACHEHPGD
SCHEMBL9712541 0.70 PGK1 (0.30)
SCHEMBL356245 0.69
SCHEMBL1145902 0.69 ALDH1A1 (0.40) CA1CYP3A4KDM4EALDH1A1ACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6914140-B1 Asymmetric synthesis process HOFFMANN-LA ROCHE INC. (US) 2005-07-05 US disclosed
EP-0869126-B1 Dithiolan derivatives, their preparation and their therapeutic effect SANKYO CO (JP) 2002-07-31 EP disclosed
US-6380179-B1 ADMINISTERING N-(1-METHYL-1-(4-METHOXYPHENYL)ETHYL)-3-OXO-4-AZA-5ALPHA-ANDRO ST-1-ENE-17BETA-CARBAXAMIDE SANKYO COMPANY, LIMITED (JP) 2002-04-30 US disclosed
US-6313164-B1 TO ENHANCE THE ACTIVITY OF GLUTATHIONE RECLUCTASE; FOR THERAPY AND PROPHYLAXIS OF CARTARACTS SANKYO COMPANY, LIMITED (JP) 2001-11-06 US disclosed
EP-1070710-A2 Dithiolan derivatives, their preparation and their therapeutic effect Sankyo Company Limited (JP) 2001-01-24 EP disclosed
US-6093722-A ADMINISTERING AN ANTICANCER DRUG N-3-OXO-4-AZA-5 ALPHA-ANDROST-1-ENE-17 BETA-CARBOXAMIDE, A TESTOSTERONE 5-ALPHA REDUCTASE ENZYME INHIBITOR SANKYO COMPANY, LIMITED (JP) 2000-07-25 US disclosed
US-6069245-A PRODUCING A 3-BENZOYLAMINO-4-BENZOYLOXYHEXAHYDROAZEPINE BY THE CATALYTIC HYDROGENATION OF THE 4-OXO-AMINE SALT DERIVATIVE; PROTECTING THE RING NITROGEN; FORMING A FUSED RING; HYDROLYSIS; ACYLATION AND DEPROTECTING HOFFMANN-LA ROCHE INC. (US) 2000-05-30 US disclosed
US-6013663-A CATARACT THERAPY OR PREVENTION SANKYO COMPANY, LIMITED (JP) 2000-01-11 US disclosed
US-5902882-A ASYMMETRICALLY HYDROGENATING AN AZEPINE COMPOUND IN THE PRESENCE OF A RUTHENIUM-DIPHOSPHINE COMPLEX CATALYST HOFFMANN-LA ROCHE INC. (US) 1999-05-11 US disclosed
CN-1208035-A Dithiolan derivatives, their preparation and their therapeutic effect SANKYO CO (JP) 1999-02-17 CN disclosed
EP-0869126-A1 Dithiolan derivatives, their preparation and their therapeutic effect Sankyo Company Limited (JP) 1998-10-07 EP disclosed
EP-0802190-A1 Process and intermediates for preparing azepines F. HOFFMANN-LA ROCHE AG (CH) 1997-10-22 EP disclosed