Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G10 | O15496 | 2/20 | 0.47 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.45 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6283587 | 0.93 | LMNA (0.48) | PLA2G10PLA2G5SCN9ASCN10AKDM4E | |
| SCHEMBL3591635 | 0.90 | PLA2G10 (0.49) | PLA2G10PLA2G5SCN9ASCN10AKDM4E | |
| SCHEMBL6283002 | 0.84 | CYP2D6 (0.65) | PLA2G10PLA2G5SCN9ASCN10AKDM4E | |
| SCHEMBL8916277 | 0.83 | PLA2G10 (0.47) | PLA2G10PLA2G5SCN9ASCN10AKDM4E | |
| SCHEMBL20571667 | 0.82 | GAA (0.47) | PLA2G10PLA2G5SCN9ASCN10AKDM4E | |
| SCHEMBL3588482 | 0.81 | SCN9A (0.53) | PLA2G10PLA2G5SCN9ASCN10AKDM4E | |
| SCHEMBL3579845 | 0.79 | PLA2G10 (0.46) | PLA2G10PLA2G5SCN9ASCN10AKDM4E | |
| SCHEMBL1364804 | 0.79 | TSHR (0.54) | PLA2G10PLA2G5KDM4EALDH1A1LMNA | |
| SCHEMBL27467093 | 0.79 | PLA2G10 (0.43) | PLA2G10PLA2G5SCN9ASCN10AKDM4E | |
| SCHEMBL13200405 | 0.79 | SCN9A (0.49) | PLA2G10PLA2G5SCN9ASCN10AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6852744-B2 | Pyrrolidine derivatives and their use as chymase inhibitor | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 2005-02-08 | — | — | US | disclosed |
| US-6835714-B1 | Heterocyclic compounds, intermediates thereof and elastase inhibitors | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 2004-12-28 | — | — | US | disclosed |
| US-20040102384-A1 | Pyrrolidine derivatives and their use as chymase inhibitor | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 2004-05-27 | — | — | US | disclosed |
| EP-1157998-B1 | HETEROCYCLIC COMPOUNDS, INTERMEDIATES THEREOF AND ELASTASE INHIBITORS | DAINIPPON PHARMACEUTICAL CO (JP) | 2004-02-11 | — | — | EP | disclosed |
| EP-1313730-A1 | PYRROLIDINE DERIVATIVES AND THEIR USE AS CHYMASE INHIBITOR | Dainippon Pharmaceutical Co., Ltd. (JP) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002018378-A1 | PYRROLIDINE DERIVATIVES AND THEIR USE AS CHYMASE INHIBITOR | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 2002-03-07 | — | — | WO | disclosed |
| EP-1157998-A1 | HETEROCYCLIC COMPOUNDS, INTERMEDIATES THEREOF AND ELASTASE INHIBITORS | Dainippon Pharmaceutical Co., Ltd. (JP) | 2001-11-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040102384-A1 | Pyrrolidine derivatives and their use as chymase inhibitor | CMA1, CTRL, TPSD1 | PLA2G10 4224/4885PLA2G5 3701/4885SCN9A 1434/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.