Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.44 |
| ▸ | PREP | P48147 | 2/20 | 0.44 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | KLK7 | P49862 | 1/20 | 0.41 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | HTR3B | O95264 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.41 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6279131 | 0.89 | GABRA1 (0.55) | GABRA1GABRA3GABRB2GABRG2GABRB3 | |
| SCHEMBL774660 | 0.86 | PREP (0.50) | GABRA1GABRA3GABRB2GABRG2GABRB3 | |
| SCHEMBL6967342 | 0.86 | PREP (0.50) | GABRA1GABRA3GABRB2GABRG2GABRB3 | |
| SCHEMBL707001 | 0.86 | PREP (0.50) | GABRA1GABRA3GABRB2GABRG2GABRB3 | |
| SCHEMBL7816472 | 0.83 | NR4A2 (0.47) | NR4A2GABRA1GABRA3GABRB2GABRG2 | |
| SCHEMBL8542318 | 0.80 | UTS2R (0.51) | GABRA1GABRA3GABRB2GABRG2GABRB3 | |
| SCHEMBL8875340 | 0.80 | UTS2R (0.51) | GABRA1GABRA3GABRB2GABRG2GABRB3 | |
| SCHEMBL16920143 | 0.79 | NR4A2 (0.61) | NR4A2GABRA1GABRA3GABRB2GABRB1 | |
| SCHEMBL8791518 | 0.79 | GABRA1 (0.46) | GABRA1GABRA3GABRB2GABRG2GABRB3 | |
| SCHEMBL6285592 | 0.76 | NR4A2 (0.46) | NR4A2UTS2RSIGMAR1HTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6914145-B2 | Acylation process | PFIZER, INC. (US) | 2005-07-05 | — | — | US | disclosed |
| EP-1088817-B1 | Process for the preparation of 3-acyl-indoles | PFIZER LTD (GB) | 2003-02-26 | — | — | EP | disclosed |
| US-20020188138-A1 | Acylation process | PFIZER INC. | 2002-12-12 | — | — | US | disclosed |
| US-6441192-B1 | ADDING ACID CHLORIDE AND ALKYL OR ARYL MAGNESIUM HALIDE SEPARATELY AND SIMULTANEOUSLY TO A STIRRED SOLUTION OF AN INDOLE SUCH THAT THE TWO REAGENTS DO NOT COME INTO IMMEDIATE CONTACT; SYNCHRONISED RATES OF MOLAR ADDITION | PFIZER INC. | 2002-08-27 | — | — | US | disclosed |
| EP-1088817-A2 | Process for the preparation of 3-acyl-indoles | Pfizer Limited (GB) | 2001-04-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020188138-A1 | Acylation process | IDO1, IDO2, AANAT | NR4A2 3114/4885GABRA1 1306/4885GABRA3 720/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.