Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.42 |
| ▸ | HTR3B | O95264 | 2/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.42 |
| ▸ | HTR3A | P46098 | 2/20 | 0.42 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.42 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.40 |
| ▸ | CHRNG | P07510 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7816472 | 0.79 | NR4A2 (0.47) | NR4A2HTR3EHTR3BCHRNB2CHRNA7 | |
| SCHEMBL6282802 | 0.76 | NR4A2 (0.44) | NR4A2HTR3EHTR3BCHRNB2CHRNA7 | |
| SCHEMBL1697438 | 0.67 | SMN1; SMN2 (0.55) | NR4A2KDM4ESMN1; SMN2HTTUTS2R | |
| SCHEMBL3796781 | 0.67 | NR4A2 (0.48) | NR4A2HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL16723480 | 0.66 | SIGMAR1 (0.45) | NR4A2SMN1; SMN2UTS2RSIGMAR1L3MBTL1 | |
| SCHEMBL2085712 | 0.66 | NR4A2 (0.69) | NR4A2KDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL774660 | 0.65 | PREP (0.50) | UTS2R | |
| SCHEMBL707001 | 0.65 | PREP (0.50) | UTS2R | |
| SCHEMBL6967342 | 0.65 | PREP (0.50) | UTS2R | |
| SCHEMBL16920143 | 0.65 | NR4A2 (0.61) | NR4A2KDM4EMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6914145-B2 | Acylation process | PFIZER, INC. (US) | 2005-07-05 | — | — | US | disclosed |
| US-20020188138-A1 | Acylation process | PFIZER INC. | 2002-12-12 | — | — | US | disclosed |
| US-6441192-B1 | ADDING ACID CHLORIDE AND ALKYL OR ARYL MAGNESIUM HALIDE SEPARATELY AND SIMULTANEOUSLY TO A STIRRED SOLUTION OF AN INDOLE SUCH THAT THE TWO REAGENTS DO NOT COME INTO IMMEDIATE CONTACT; SYNCHRONISED RATES OF MOLAR ADDITION | PFIZER INC. | 2002-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020188138-A1 | Acylation process | IDO1, IDO2, AANAT | NR4A2 3114/4885HTR3E 165/4885HTR3B 110/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.