Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 14/20 | 0.72 |
| ▸ | BCHE | P06276 | 2/20 | 0.40 |
| ▸ | NOS3 | P29474 | 9/20 | 0.40 |
| ▸ | NOS2 | P35228 | 6/20 | 0.40 |
| ▸ | QRFPR | Q96P65 | 4/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6283540 | 1.00 | NOS1 (0.72) | NOS1BCHENOS3NOS2QRFPR | |
| SCHEMBL6276210 | 0.94 | NOS1 (0.64) | NOS1BCHENOS3NOS2QRFPR | |
| SCHEMBL6280535 | 0.85 | NOS1 (0.73) | NOS1BCHENOS3QRFPRACHE | |
| SCHEMBL6280536 | 0.85 | NOS1 (0.73) | NOS1BCHENOS3QRFPRACHE | |
| SCHEMBL6280881 | 0.84 | NOS1 (1.00) | NOS1BCHEACHE | |
| SCHEMBL6280885 | 0.84 | NOS1 (1.00) | NOS1BCHEACHE | |
| SCHEMBL6599622 | 0.83 | NOS1 (0.61) | NOS1NOS3NOS2 | |
| SCHEMBL6599626 | 0.83 | NOS1 (0.61) | NOS1NOS3NOS2 | |
| SCHEMBL5382722 | 0.80 | NOS1 (0.56) | NOS1NOS3NOS2QRFPR | |
| SCHEMBL5382719 | 0.80 | NOS1 (0.56) | NOS1NOS3NOS2QRFPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040019084-A1 | New derivatives of lipoic acid, their preparation, their use as medicaments and the pharmaceutical compositions containing them | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATION SCIENTIFIQUES (S.C.R.A.S) | 2004-01-29 | — | — | US | claimed |
| EP-1169316-B9 | NOVEL LIPOIC ACID DERIVATIVES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SOD CONSEILS RECH APPLIC (FR) | 2003-10-29 | — | — | EP | claimed |
| EP-1169316-B1 | NOVEL LIPOIC ACID DERIVATIVES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SOD CONSEILS RECH APPLIC (FR) | 2003-03-05 | — | — | EP | claimed |
| JP-2003505341-A | — | — | 2003-02-12 | — | — | JP | claimed |
| EP-1169316-A1 | NOVEL LIPOIC ACID DERIVATIVES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2002-01-09 | — | — | EP | claimed |
| WO-2000059899-A1 | NOVEL LIPOIC ACID DERIVATIVES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SOCIETE DE CONSEIL DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2000-10-12 | — | — | WO | claimed |
| US-6887891-B2 | Derivatives of lipoic acid, their preparation, their use as medicaments and the pharmaceutical compositions containing them | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2005-05-03 | — | — | US | disclosed |
| US-20040019084-A1 | New derivatives of lipoic acid, their preparation, their use as medicaments and the pharmaceutical compositions containing them | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATION SCIENTIFIQUES (S.C.R.A.S) | 2004-01-29 | — | — | US | disclosed |
| EP-1169316-B9 | NOVEL LIPOIC ACID DERIVATIVES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SOD CONSEILS RECH APPLIC (FR) | 2003-10-29 | — | — | EP | disclosed |
| US-6605637-B1 | Nitrogen monoxide synthase inhibitors; such as n-(4-(((2-thienyl)(imino)methyl)amino)phenyl)-1,2-dithiolane-3-pentamide | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2003-08-12 | — | — | US | disclosed |
| EP-1169316-B1 | NOVEL LIPOIC ACID DERIVATIVES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SOD CONSEILS RECH APPLIC (FR) | 2003-03-05 | — | — | EP | disclosed |
| EP-1169316-A1 | NOVEL LIPOIC ACID DERIVATIVES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2002-01-09 | — | — | EP | disclosed |
| WO-2000059899-A1 | NOVEL LIPOIC ACID DERIVATIVES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SOCIETE DE CONSEIL DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2000-10-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040019084-A1 | New derivatives of lipoic acid, their preparation, their use as medicaments and the pharmaceutical compositions containing them | NOS1, NOS2, LPO | NOS1 1/4885BCHE 1559/4885NOS3 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.