Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 2/20 | 0.56 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.47 |
| ▸ | NAAA | Q02083 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6316189 | 0.93 | HRH1 (0.59) | HRH1LOXL2CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL317695 | 0.84 | — | — | |
| SCHEMBL726645 | 0.84 | HRH1 (0.73) | HRH1LOXL2CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL351920 | 0.84 | HRH1 (0.65) | HRH1LOXL2CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL31673871 | 0.81 | HRH1 (0.62) | HRH1LOXL2CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL28055322 | 0.81 | HRH1 (0.62) | HRH1LOXL2CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL4413800 | 0.81 | HRH1 (0.77) | HRH1LOXL2CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL2841394 | 0.81 | HRH1 (0.77) | HRH1LOXL2CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL725306 | 0.81 | HRH1 (0.77) | HRH1LOXL2CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL151822 | 0.78 | LOXL2 (0.68) | HRH1LOXL2CYP3A4CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6921762-B2 | Substituted indolizine-like compounds and methods of use | AMGEN INC. (US) | 2005-07-26 | — | — | US | disclosed |