Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ASPH | Q12797 | 1/20 | 0.34 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | TOP2A | P11388 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5510128 | 0.93 | HDAC1 (0.36) | HDAC1HDAC6TLR8TLR7ADORA2A | |
| SCHEMBL27666669 | 0.87 | HTT (0.42) | HDAC1HDAC6MEN1ALDH1A1TP53 | |
| SCHEMBL5617080 | 0.87 | HTT (0.42) | HDAC1HDAC6MEN1ALDH1A1TP53 | |
| SCHEMBL3352911 | 0.83 | KDM4E (0.46) | HDAC1HDAC6ADORA2AADORA1BCHE | |
| SCHEMBL1950078 | 0.82 | POLB (0.46) | MEN1ALDH1A1KMT2ATOP2ABCHE | |
| SCHEMBL6281042 | 0.81 | LMNA (0.42) | HDAC1HDAC6MEN1ALDH1A1KMT2A | |
| SCHEMBL6281044 | 0.81 | LMNA (0.42) | HDAC1HDAC6MEN1ALDH1A1KMT2A | |
| SCHEMBL1233374 | 0.81 | KDM4E (0.46) | ADORA2AADORA1ADORA2BBCHE | |
| SCHEMBL5617083 | 0.81 | TOP2A (0.51) | HDAC1HDAC6TLR8TLR7MEN1 | |
| SCHEMBL27670113 | 0.81 | TLR8 (0.36) | HDAC1HDAC6TLR8TLR7MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6894165-B2 | Imidazonaphthyridines | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2005-05-17 | — | — | US | disclosed |
| US-20040204436-A1 | Imidazonaphthyridines | MEDICIS PHARMACEUTICAL CORPORATION | 2004-10-14 | — | — | US | disclosed |
| US-6699878-B2 | Imidazonaphthyridines | 3M INNOVATIVE PROPERTIES COMPANY | 2004-03-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040204436-A1 | Imidazonaphthyridines | IFNG, IRF3, IFNAR1 | HDAC1 1650/4885HDAC6 1469/4885TLR8 186/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.