SCHEMBL6284593

SCHEMBL6284593

Nc1ccc(-c2nc3ccccc3s2)cc1Cl

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
APP P05067 8/20 0.69
MMP9 P14780 2/20 0.62
MMP8 P22894 2/20 0.62
RAB9A P51151 9/20 0.61
NPC1 O15118 7/20 0.61
KDM4E B2RXH2 6/20 0.61
MAPT P10636 5/20 0.61
MEN1 O00255 4/20 0.61
KMT2A Q03164 4/20 0.61
ALDH1A1 P00352 4/20 0.61
NFKB1 P19838 3/20 0.61
NFKB2 Q00653 3/20 0.61
RELA Q04206 3/20 0.61
L3MBTL1 Q9Y468 2/20 0.57
PAX8 Q06710 1/20 0.57
NOD2 Q9HC29 1/20 0.57
SMN1; SMN2 Q16637 4/20 0.54
LMNA P02545 3/20 0.54
GAA P10253 3/20 0.54
GLA P06280 2/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26269084 0.93 RAB9A (0.62) APPMMP9MMP8RAB9ANPC1
SCHEMBL2249002 0.88 APP (0.65) APPMMP9MMP8RAB9ANPC1
SCHEMBL7836371 0.86 APP (0.75) APPMMP9MMP8RAB9ANPC1
Hydrochloric Acid SCHEMBL6285762 0.86 MAPT (0.53) APPMMP9MMP8RAB9ANPC1
SCHEMBL8397690 0.84 APP (0.73) APPMMP9MMP8RAB9ANPC1
SCHEMBL11744302 0.83 MAPT (0.68) APPRAB9ANPC1KDM4EMAPT
SCHEMBL1726512 0.82 APP (1.00) APPMMP9MMP8RAB9ANPC1
SCHEMBL1978135 0.82 APP (0.69) APPMMP9MMP8RAB9ANPC1
SCHEMBL29406270 0.82 APP (0.69) APPMMP9MMP8RAB9ANPC1
SCHEMBL1326042 0.82 APP (0.69) APPMMP9MMP8RAB9ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0812319-B9 2-ARYLBENZAZOLE COMPOUNDS CANCER RES VENTURES LTD (GB) 2003-10-08 EP claimed
EP-0812319-B1 2-ARYLBENZAZOLE COMPOUNDS CANCER RES VENTURES LTD (GB) 2002-07-10 EP claimed
US-6034246-A ANTICANCER AGENT CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) 2000-03-07 US claimed
WO-1996026932-A1 2-ARYLBENZAZOLE COMPOUNDS CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) 1996-09-06 WO claimed
US-6858633-B1 Substituted 2-arylbenzazole compounds and their use as antitumour agents CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2005-02-22 US disclosed
EP-0812319-B9 2-ARYLBENZAZOLE COMPOUNDS CANCER RES VENTURES LTD (GB) 2003-10-08 EP disclosed
EP-0812319-B1 2-ARYLBENZAZOLE COMPOUNDS CANCER RES VENTURES LTD (GB) 2002-07-10 EP disclosed
EP-1204650-A1 SUBSTITUTED 2-ARYLBENZAZOLE COMPOUNDS AND THEIR USE AS ANTITUMOUR AGENTS Cancer Research Ventures Limited (GB) 2002-05-15 EP disclosed
WO-2001014354-A1 SUBSTITUTED 2-ARYLBENZAZOLE COMPOUNDS AND THEIR USE AS ANTITUMOUR AGENTS CANCER RESEARCH VENTURES LIMITED (GB) 2001-03-01 WO disclosed
US-6034246-A ANTICANCER AGENT CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) 2000-03-07 US disclosed
EP-0812319-A1 2-ARYLBENZAZOLE COMPOUNDS CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) 1997-12-17 EP disclosed
WO-1996026932-A1 2-ARYLBENZAZOLE COMPOUNDS CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) 1996-09-06 WO disclosed