Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 7/20 | 0.69 |
| ▸ | MMP9 | P14780 | 2/20 | 0.62 |
| ▸ | MMP8 | P22894 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 8/20 | 0.61 |
| ▸ | NPC1 | O15118 | 7/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.61 |
| ▸ | MEN1 | O00255 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.61 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.61 |
| ▸ | RELA | Q04206 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | GLA | P06280 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7836371 | 0.86 | APP (0.75) | APPMMP9MMP8RAB9ANPC1 | |
| SCHEMBL1326042 | 0.85 | APP (0.69) | APPMMP9MMP8RAB9ANPC1 | |
| SCHEMBL29406270 | 0.85 | APP (0.69) | APPMMP9MMP8RAB9ANPC1 | |
| SCHEMBL8397690 | 0.84 | APP (0.73) | APPMMP9MMP8RAB9ANPC1 | |
| SCHEMBL18875264 | 0.84 | APP (0.57) | APPMMP9MMP8RAB9ANPC1 | |
| SCHEMBL7104870 | 0.84 | APP (0.61) | APPMMP9MMP8RAB9ANPC1 | |
| SCHEMBL1726512 | 0.82 | APP (1.00) | APPMMP9MMP8RAB9ANPC1 | |
| SCHEMBL6284593 | 0.82 | APP (0.69) | APPMMP9MMP8RAB9ANPC1 | |
| SCHEMBL12471564 | 0.82 | KDM4E (0.64) | APPMMP9MMP8RAB9ANPC1 | |
| SCHEMBL12227064 | 0.82 | APP (0.69) | APPMMP9MMP8RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008136018-A2 | 4BETA-AMIN0 PODOPHYLLOTOXIN CONGENERS AS POTENTIAL ANTICANCER AGENTS AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2008-11-13 | — | — | WO | claimed |
| US-20080275248-A1 | NOVEL 4BETA-AMINO PODOPHYLLOTOXIN CONGENERS AS POTENTIAL ANTICANCER AGENTS AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2008-11-06 | — | — | US | claimed |
| EP-0812319-B9 | 2-ARYLBENZAZOLE COMPOUNDS | CANCER RES VENTURES LTD (GB) | 2003-10-08 | — | — | EP | claimed |
| EP-0812319-B1 | 2-ARYLBENZAZOLE COMPOUNDS | CANCER RES VENTURES LTD (GB) | 2002-07-10 | — | — | EP | claimed |
| US-6034246-A | ANTICANCER AGENT | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 2000-03-07 | — | — | US | claimed |
| WO-1996026932-A1 | 2-ARYLBENZAZOLE COMPOUNDS | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 1996-09-06 | — | — | WO | claimed |
| EP-3296294-B1 | COMPOUND FOR TREATING OR PREVENTING BREAST CANCER | JIANGSU ATOM BIOSCIENCE AND PHARMACEUTICAL CO LTD (CN) | 2020-02-12 | — | — | EP | disclosed |
| EP-3296294-A1 | COMPOUND FOR TREATING OR PREVENTING BREAST CANCER | Jiangsu Atom Bioscience And Pharmaceutical Co., Ltd (CN) | 2018-03-21 | — | — | EP | disclosed |
| US-7960418-B2 | Cytotoxic 4 beta -[4''-(1'',3''-benzothiazole-2''-yl)anilino]-4-desoxypodophyllotoxin anticarcinogenic agent; prepared by amination with a 4-(1,3-benzothiazole-2-yl)aniline compound; new chemical derivatives from PODOPHYLLOTOXIN, as antitumor antibiotics | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2011-06-14 | — | — | US | disclosed |
| WO-2008136018-A2 | 4BETA-AMIN0 PODOPHYLLOTOXIN CONGENERS AS POTENTIAL ANTICANCER AGENTS AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2008-11-13 | — | — | WO | disclosed |
| US-20080275248-A1 | NOVEL 4BETA-AMINO PODOPHYLLOTOXIN CONGENERS AS POTENTIAL ANTICANCER AGENTS AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2008-11-06 | — | — | US | disclosed |
| EP-0812319-B9 | 2-ARYLBENZAZOLE COMPOUNDS | CANCER RES VENTURES LTD (GB) | 2003-10-08 | — | — | EP | disclosed |
| EP-0812319-B1 | 2-ARYLBENZAZOLE COMPOUNDS | CANCER RES VENTURES LTD (GB) | 2002-07-10 | — | — | EP | disclosed |
| US-6034246-A | ANTICANCER AGENT | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 2000-03-07 | — | — | US | disclosed |
| WO-1996026932-A1 | 2-ARYLBENZAZOLE COMPOUNDS | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 1996-09-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080275248-A1 | NOVEL 4BETA-AMINO PODOPHYLLOTOXIN CONGENERS AS POTENTIAL ANTICANCER AGENTS AND A PROCESS FOR THE PREPARATION THEREOF | IPO4, TUBB4B, TUBB4A | APP 4824/4885MMP9 2874/4885MMP8 3732/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.