Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1556809 | 0.85 | CYP2D6 (0.50) | ALDH1A1SIGMAR1NAMPTCYP2D6TSHR | |
| SCHEMBL4875396 | 0.79 | CYP2D6 (0.55) | ALDH1A1SIGMAR1CYP2D6SMN1; SMN2TSHR | |
| SCHEMBL21538553 | 0.76 | MEN1 (0.50) | ALDH1A1POLBSIGMAR1CYP2D6TSHR | |
| SCHEMBL6012315 | 0.75 | MEN1 (0.37) | ALDH1A1SIGMAR1CYP2D6SMN1; SMN2TSHR | |
| SCHEMBL24324296 | 0.75 | MAPT (0.40) | ALDH1A1SIGMAR1CYP2D6SMN1; SMN2SLC6A2 | |
| SCHEMBL6012435 | 0.75 | SIGMAR1 (0.53) | ALDH1A1SIGMAR1HTR3ACYP2D6TSHR | |
| SCHEMBL323276 | 0.75 | CYP2D6 (0.52) | ALDH1A1SIGMAR1CYP2D6SMN1; SMN2TSHR | |
| Hydrochloric Acid SCHEMBL322816 | 0.74 | CYP2D6 (0.51) | ALDH1A1POLBSIGMAR1CYP2D6SMN1; SMN2 | |
| SCHEMBL6012414 | 0.72 | SIGMAR1 (0.44) | ALDH1A1SIGMAR1HTR3ASMN1; SMN2SLC6A2 | |
| SCHEMBL518379 | 0.72 | ALDH1A1 (0.44) | ALDH1A1POLBHTR3ATSHRKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050171183-A1 | Indole-type inhibitors of p38 kinase | SCIOS, INC. (US) | 2005-08-04 | — | — | US | disclosed |
| US-6890938-B2 | Indole-type inhibitors of p38 kinase | SCIOS, INC. (US) | 2005-05-10 | — | — | US | disclosed |
| EP-1339708-A2 | INDOLE-TYPE INHIBITORS OF P38 KINASE | Scios Inc. (US) | 2003-09-03 | — | — | EP | disclosed |
| US-20030100588-A1 | Indole-type inhibitors of p38 kinase | SCIOS, INC. | 2003-05-29 | — | — | US | disclosed |
| WO-2002044168-A2 | INDOLE-TYPE INHIBITORS OF P38 KINASE | SCIOS INC. (US) | 2002-06-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030100588-A1 | Indole-type inhibitors of p38 kinase | CNKSR1, MAPK1, MAP2K6 | ALDH1A1 3213/4885POLB 4206/4885CNR2 364/4885 |
| US-20050171183-A1 | Indole-type inhibitors of p38 kinase | MAPK1, MAPKAPK2, MAP3K1 | ALDH1A1 1628/4885POLB 2524/4885CNR2 1821/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.