SCHEMBL6284697

SCHEMBL6284697

COc1ccc(C(OC[C@@H]2O[C@H](n3ccc(=O)[nH]c3=O)C(OC)C2O)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.53

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
TYMP P19971 1/20 0.53
P2RY14 Q15391 5/20 0.51
P2RY2 P41231 10/20 0.46
P2RY6 Q15077 8/20 0.46
P2RY4 P51582 4/20 0.45
SLC28A1 O00337 1/20 0.44
SLC28A2 O43868 1/20 0.44
SLC29A1 Q99808 1/20 0.44
SLC28A3 Q9HAS3 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6284695 1.00 TYMP (0.53) TYMPP2RY14P2RY2P2RY6P2RY4
SCHEMBL3721728 1.00 TYMP (0.53) TYMPP2RY14P2RY2P2RY6P2RY4
SCHEMBL19709158 1.00 TYMP (0.53) TYMPP2RY14P2RY2P2RY6P2RY4
SCHEMBL19709160 1.00 TYMP (0.53) TYMPP2RY14P2RY2P2RY6P2RY4
SCHEMBL19549038 1.00 TYMP (0.53) TYMPP2RY14P2RY2P2RY6P2RY4
SCHEMBL20828930 1.00 TYMP (0.53) TYMPP2RY14P2RY2P2RY6P2RY4
SCHEMBL13837117 0.93 TYMP (0.52) TYMPP2RY14P2RY2P2RY6P2RY4
SCHEMBL20603110 0.93 TYMP (0.52) TYMPP2RY14P2RY2P2RY6P2RY4
SCHEMBL21905171 0.93 TYMP (0.52) TYMPP2RY14P2RY2P2RY6P2RY4
SCHEMBL10592428 0.93 TYMP (0.53) TYMPP2RY14P2RY2P2RY6P2RY4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025063238-A1 SIRNA FOR SUPPRESSING EXPRESSION OF PHOSPHOLAMBAN 第一三共株式会社 2025-03-27 WO disclosed
WO-2025063239-A1 SIRNA CAPABLE OF SUPPRESSING EXPRESSION OF α-SYNUCLEIN 第一三共株式会社 2025-03-27 WO disclosed
US-20240018180-A1 OLIGONUCLEOTIDE PRODUCTION METHOD AJINOMOTO CO., INC. (JP) 2024-01-18 US disclosed
EP-4293035-A1 OLIGONUCLEOTIDE PRODUCTION METHOD AJINOMOTO CO., INC. (JP) 2023-12-20 EP disclosed
WO-2022172994-A1 OLIGONUCLEOTIDE PRODUCTION METHOD 味の素株式会社 2022-08-18 WO disclosed
US-6884881-B1 2′-Substituted RNA preparation AVECIA LIMITED (GB) 2005-04-26 US disclosed
EP-1165584-B1 2'-SUBSTITUTED RNA PREPARATION AVECIA LTD (GB) 2004-01-21 EP disclosed
US-6090932-A Method of preparation of known and novel 2'-modified nucleosides by intramolecular nucleophilic displacement PROLIGO LLC (US) 2000-07-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240018180-A1 OLIGONUCLEOTIDE PRODUCTION METHOD RNGTT, NOX4, POLRMT TYMP 101/4885P2RY14 2303/4885P2RY2 2567/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.