Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 1/20 | 0.36 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.36 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.36 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.36 |
| ▸ | LGALS8 | O00214 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | MGAM | O43451 | 2/20 | 0.33 |
| ▸ | SI | P14410 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13191783 | 1.00 | PI4KA (0.36) | PI4KAPI4K2BPI4K2API4KBLGALS8 | |
| SCHEMBL2621340 | 1.00 | PI4KA (0.36) | PI4KAPI4K2BPI4K2API4KBLGALS8 | |
| SCHEMBL7230050 | 1.00 | PI4KA (0.36) | PI4KAPI4K2BPI4K2API4KBLGALS8 | |
| SCHEMBL13912806 | 1.00 | PI4KA (0.36) | PI4KAPI4K2BPI4K2API4KBLGALS8 | |
| SCHEMBL14709162 | 1.00 | PI4KA (0.36) | PI4KAPI4K2BPI4K2API4KBLGALS8 | |
| SCHEMBL24481795 | 1.00 | PI4KA (0.36) | PI4KAPI4K2BPI4K2API4KBLGALS8 | |
| SCHEMBL8524155 | 1.00 | PI4KA (0.36) | PI4KAPI4K2BPI4K2API4KBLGALS8 | |
| SCHEMBL12940449 | 1.00 | PI4KA (0.36) | PI4KAPI4K2BPI4K2API4KBLGALS8 | |
| SCHEMBL12902288 | 1.00 | PI4KA (0.36) | PI4KAPI4K2BPI4K2API4KBLGALS8 | |
| SCHEMBL18862675 | 1.00 | PI4KA (0.36) | PI4KAPI4K2BPI4K2API4KBLGALS8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160304478-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2016-10-20 | — | — | US | disclosed |
| US-20160304478-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2016-10-20 | — | — | US | disclosed |
| US-9428452-B2 | Compounds | GLAXO GROUP LIMITED (GB) | 2016-08-30 | — | — | US | disclosed |
| US-9428452-B2 | Compounds | GLAXO GROUP LIMITED (GB) | 2016-08-30 | — | — | US | disclosed |
| US-20150080369-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2015-03-19 | — | — | US | disclosed |
| US-20150080369-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2015-03-19 | — | — | US | disclosed |
| WO-2013160418-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2013-10-31 | — | — | WO | disclosed |
| US-6927294-B1 | Nitrogen-containing heterocycles | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2005-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150080369-A1 | NOVEL COMPOUNDS | RORC, RORB, RORA | PI4KA 1520/4885PI4K2B 2238/4885PI4K2A 2297/4885 |
| US-20160304478-A1 | NOVEL COMPOUNDS | RORC, RORB, RORA | PI4KA 1520/4885PI4K2B 2238/4885PI4K2A 2297/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.