Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 1/20 | 0.49 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 9/20 | 0.38 |
| ▸ | RXRB | P28702 | 8/20 | 0.38 |
| ▸ | RXRG | P48443 | 6/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3995073 | 0.83 | TRPV1 (0.50) | TBXAS1TRPV1PSEN1PSEN2APH1B | |
| SCHEMBL3995067 | 0.83 | TRPV1 (0.50) | TBXAS1TRPV1PSEN1PSEN2APH1B | |
| SCHEMBL10967937 | 0.80 | GABBR2 (0.54) | HMGCRCYP3A4TP53MAPTALOX15 | |
| SCHEMBL10494818 | 0.80 | GABBR2 (0.54) | HMGCRCYP3A4TP53MAPTALOX15 | |
| SCHEMBL689069 | 0.78 | HMGCR (0.46) | HMGCRRXRARXRBRXRGCYP3A4 | |
| SCHEMBL11306370 | 0.75 | GABBR2 (0.46) | HMGCRCYP3A4TP53MAPTALOX15 | |
| SCHEMBL5173409 | 0.75 | TBXAS1 (0.58) | TBXAS1CYP3A4TP53EPHX2PPARG | |
| Ethylene SCHEMBL30620437 | 0.75 | HMGCR (0.44) | HMGCRRXRARXRBRXRGCYP3A4 | |
| SCHEMBL9487398 | 0.75 | RPS6KA3 (0.53) | CYP3A4 | |
| SCHEMBL2389163 | 0.74 | CYP2C9 (0.46) | TBXAS1CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991016892-A1 | STYRYL COMPOUNDS WHICH INHIBIT EGF RECEPTOR PROTEIN TYROSINE KINASE | RORER INTERNATIONAL (HOLDINGS), INC. (US) | 1991-11-14 | — | — | WO | claimed |
| US-RE38761-E1 | Styryl compounds which inhibit EGF receptor protein tyrosine kinase | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2005-07-19 | — | — | US | disclosed |
| US-5217999-A | Antigrowth agents | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 1993-06-08 | — | — | US | disclosed |
| WO-1991016892-A1 | STYRYL COMPOUNDS WHICH INHIBIT EGF RECEPTOR PROTEIN TYROSINE KINASE | RORER INTERNATIONAL (HOLDINGS), INC. (US) | 1991-11-14 | — | — | WO | disclosed |