Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 1.00 |
| ▸ | GAA | P10253 | 5/20 | 1.00 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.45 |
| ▸ | TSHR | P16473 | 5/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.45 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.39 |
| ▸ | NSD2 | O96028 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29363940 | 1.00 | MAPT (1.00) | MAPTKDM4EGAAMCL1ALDH1A1 | |
| SCHEMBL28279 | 1.00 | MAPT (1.00) | MAPTKDM4EGAAMCL1ALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL6838810 | 0.97 | MAPT (0.95) | MAPTKDM4EGAAMCL1ALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL9336609 | 0.97 | MAPT (0.95) | MAPTKDM4EGAAMCL1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9815129 | 0.97 | MAPT (0.95) | MAPTKDM4EGAAMCL1ALDH1A1 | |
| SCHEMBL30833304 | 0.97 | MAPT (0.95) | MAPTKDM4EGAAMCL1ALDH1A1 | |
| SCHEMBL1509347 | 0.92 | MAPT (0.85) | MAPTKDM4EGAAMCL1ALDH1A1 | |
| N,N-Dimethylethanaminium SCHEMBL8487667 | 0.89 | KDM4E (0.78) | MAPTKDM4EGAAMCL1ALDH1A1 | |
| Formic Acid SCHEMBL7595259 | 0.87 | MAPT (0.75) | MAPTKDM4EGAAMCL1ALDH1A1 | |
| Phosphoric Acid SCHEMBL9139860 | 0.87 | MAPT (0.75) | MAPTKDM4EGAAMCL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230278989-A1 | ISOINDOLINONE INHIBITORS OF THE MDM2-P53 INTERACTION AND PROCESS FOR MAKING THEM | ASTEX THERAPEUTICS LIMITED (GB) | 2023-09-07 | — | — | US | claimed |
| US-20210101887-A1 | ISOINDOLINONE INHIBITORS OF THE MDM2-P53 INTERACTION AND PROCESS FOR MAKING THEM | ASTEX THERAPEUTICS LIMITED (GB) | 2021-04-08 | — | — | US | claimed |
| US-20230278989-A1 | ISOINDOLINONE INHIBITORS OF THE MDM2-P53 INTERACTION AND PROCESS FOR MAKING THEM | ASTEX THERAPEUTICS LIMITED (GB) | 2023-09-07 | — | — | US | disclosed |
| US-11603367-B2 | Isoindolinone inhibitors of the MDM2-P53 interaction and process for making them | ASTEX THERAPEUTICS LIMITED (GB) | 2023-03-14 | — | — | US | disclosed |
| US-20210101887-A1 | ISOINDOLINONE INHIBITORS OF THE MDM2-P53 INTERACTION AND PROCESS FOR MAKING THEM | ASTEX THERAPEUTICS LIMITED (GB) | 2021-04-08 | — | — | US | disclosed |
| US-20050164125-A1 | Forming layer of photoimageable composition on a substrate surface exposed to pattern of radiation which produces a catalyst capable of changing photoimageable composition's susceptibility to a developer | SANDIA NATIONAL LABORATORIES (US) | 2005-07-28 | — | — | US | disclosed |
| US-20050118529-A1 | Photoimageable composition | SANDIA NATIONAL LABORATORIES (US) | 2005-06-02 | — | — | US | disclosed |
| US-6858378-B1 | Forming a layer of photoimageable composition on a substrate surface; exposing to pattern of radiation which produces a catalyst capable of changing photoimageable composition's susceptibility to a developer; applying a developer to remove | SANDIA NATIONAL LABORATORIES (US) | 2005-02-22 | — | — | US | disclosed |
| US-6645696-B1 | Selected buffering amines in a photoimageable composition prevents process bias which with conventional photoresists causes designed features to be distorted, especially in corners and high resolution features. Amines reacted with | EUV LLC. | 2003-11-11 | — | — | US | disclosed |
| US-4963552-A | HYPOTENSIVE AGENTS, ANTIDEPRESSANTS | AMERICAN CYANAMID COMPANY (US) | 1990-10-16 | — | — | US | disclosed |
| US-4916137-A | 5-(Substituted-amino)-8-(phenyl or substituted-phenyl)-3H,6H-1,4,5A,8A-tetraazaacenaphthylen-3-ones and treatment of neural behavior disorders | AMERICAN CYANAMID COMPANY (US) | 1990-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11603367-B2 | Isoindolinone inhibitors of the MDM2-P53 interaction and process for making them | MDM2, TP53, TP53BP1 | MAPT 1045/4885KDM4E 3104/4885GAA 3070/4885 |
| US-20230278989-A1 | ISOINDOLINONE INHIBITORS OF THE MDM2-P53 INTERACTION AND PROCESS FOR MAKING THEM | MDM2, TP53, TP53BP1 | MAPT 1045/4885KDM4E 3104/4885GAA 3070/4885 |
| US-20210101887-A1 | ISOINDOLINONE INHIBITORS OF THE MDM2-P53 INTERACTION AND PROCESS FOR MAKING THEM | MDM2, TP53, TP53BP1 | MAPT 1045/4885KDM4E 3104/4885GAA 3070/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.