Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | NAAA | Q02083 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3796868 | 0.85 | MEN1 (0.44) | NPC1TDP1SMN1; SMN2POLBHPGD | |
| SCHEMBL3801355 | 0.83 | YAP1 (0.45) | NPC1TDP1POLBKMT2AMEN1 | |
| SCHEMBL3797896 | 0.77 | ME2 (0.64) | NPC1TDP1HTTPOLBALDH1A1 | |
| SCHEMBL2824681 | 0.76 | MAPT (0.62) | SMN1; SMN2HTTHPGDKMT2AMEN1 | |
| SCHEMBL3796066 | 0.76 | MEN1 (0.54) | SMN1; SMN2KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL3799763 | 0.76 | GFER (0.62) | NPC1SMN1; SMN2HTTPOLBHPGD | |
| SCHEMBL2824049 | 0.76 | KMT2A (0.64) | NPC1TDP1SMN1; SMN2POLBKMT2A | |
| SCHEMBL15258825 | 0.76 | HTT (0.57) | SMN1; SMN2HTTPOLBKMT2AMEN1 | |
| SCHEMBL3796307 | 0.73 | ME2 (0.56) | SMN1; SMN2HTTHPGDALDH1A1LMNA | |
| SCHEMBL2820894 | 0.73 | RAB9A (0.57) | SMN1; SMN2HTTKMT2AMEN1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107108467-A | cell necrosis inhibitor | 北京生命科学研究所 | 2017-08-29 | — | — | CN | disclosed |
| US-6921762-B2 | Substituted indolizine-like compounds and methods of use | AMGEN INC. (US) | 2005-07-26 | — | — | US | disclosed |