Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 6/20 | 0.59 |
| ▸ | CA2 | P00918 | 6/20 | 0.59 |
| ▸ | CES2 | O00748 | 2/20 | 0.57 |
| ▸ | CES1 | P23141 | 2/20 | 0.57 |
| ▸ | PLK1 | P53350 | 1/20 | 0.55 |
| ▸ | PARP1 | P09874 | 1/20 | 0.53 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.53 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.53 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1374066 | 0.84 | ALDH1A1 (0.64) | CA1CA2CES2CES1PLK1 | |
| P-Methoxy-Acetophenone SCHEMBL28038884 | 0.79 | MAPT (0.55) | CA1CA2CES2CES1PLK1 | |
| SCHEMBL11136993 | 0.79 | ALDH1A1 (0.58) | CA1CA2CES2CES1HDAC3 | |
| SCHEMBL153386 | 0.77 | ALDH1A1 (0.76) | CA1CA2CES2CES1PLK1 | |
| P-Methoxy-Acetophenone SCHEMBL41285 | 0.76 | MAPT (0.70) | CA1CA2CES2CES1PLK1 | |
| SCHEMBL5857541 | 0.76 | NPC1 (0.65) | CA1CA2PLK1NPC1RAB9A | |
| SCHEMBL1987861 | 0.75 | CA1 (0.61) | CA1CA2CES2CES1PLK1 | |
| SCHEMBL6283202 | 0.74 | MMP1 (0.67) | CES2CES1HDAC3HDAC4HDAC1 | |
| P-Methoxy-Acetophenone SCHEMBL9835038 | 0.74 | MAPT (0.67) | CA1CA2CES2CES1PLK1 | |
| Methyl 4-Methoxybenzoate SCHEMBL231243 | 0.74 | CA1 (1.00) | CA1CA2CES2CES1PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1514542-B1 | Medicinal composition comprising Tacrine or Donepezil for improving brain function. | TOYAMA CHEMICAL CO LTD (JP) | 2012-02-22 | — | — | EP | claimed |