SCHEMBL6288232

SCHEMBL6288232

O=S(=O)(O)c1ccccc1N1CCNC(Br)C1

nearest known ligand 0.43

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
HTR6 P50406 8/20 0.43
MYC P01106 1/20 0.41
ADRB1 P08588 4/20 0.33
DRD2 P14416 1/20 0.33
NOTUM Q6P988 2/20 0.32
CA12 O43570 1/20 0.31
CA2 P00918 1/20 0.31
CA7 P43166 1/20 0.31
CA9 Q16790 1/20 0.31
RPS6KB1 P23443 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2849210 0.84 MYC (0.45) HTR6MYCDRD2
Water SCHEMBL5996484 0.83 MYC (0.44) HTR6MYCDRD2
SCHEMBL6849293 0.83 HTR6 (0.43) HTR6MYCADRB1DRD2NOTUM
SCHEMBL6849062 0.81 RPS6KB1 (0.47) HTR6MYCNOTUMRPS6KB1
SCHEMBL6848056 0.80 LATS1 (0.40) HTR6MYCADRB1DRD2NOTUM
SCHEMBL6847420 0.80 HDAC1 (0.41) HTR6MYCADRB1DRD2
SCHEMBL2851145 0.78 ADRB1 (0.41) HTR6MYCADRB1DRD2CA2
SCHEMBL6847591 0.78 HTR6 (0.39) HTR6MYCNOTUM
SCHEMBL8632814 0.77 HTR6 (0.67) HTR6MYCADRB1DRD2
Water SCHEMBL6904877 0.76 HTR6 (0.65) HTR6MYCADRB1DRD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-100486574-C Remedies and/or preventives for nervous system disorders MITSUBISHI PHARMACEUTICALS INC (JP) 2009-05-13 CN claimed
CN-1946396-A Medicine for prevention and/or treatment of ischemic circulatory disease MITSUBISHI PHARMA CORP (JP) 2007-04-11 CN claimed
CN-1638773-A Pharmaceutical preparation containing aminobenzenesulfonic acid derivative as active ingredient MITSUBISHI PHARMA CORP (JP) 2005-07-13 CN claimed
CN-1533292-A Medicament inhititing sodium/calcium exchange system 三菱制药株式会社 2004-09-29 CN claimed
CN-1496261-A Remedies and/or preventives for diabetic ischemic heart diseases 三菱制药株式会社 2004-05-12 CN claimed
EP-1374868-A1 REMEDIES AND/OR PREVENTIVES FOR DIABETIC ISCHEMIC HEART DISEASES Mitsubishi Pharma Corporation (JP) 2004-01-02 EP claimed
CN-1434724-A Remedies and/or preventives for nervous system disorders MITSUBISHI PHARMACEUTICALS INC (JP) 2003-08-06 CN claimed
CN-100502861-C Medicament inhibiting sodium/calcium exchange system MITSUBISHI PHARMA CORP (JP) 2009-06-24 CN disclosed
CN-100486574-C Remedies and/or preventives for nervous system disorders MITSUBISHI PHARMACEUTICALS INC (JP) 2009-05-13 CN disclosed
CN-1946396-A Medicine for prevention and/or treatment of ischemic circulatory disease MITSUBISHI PHARMA CORP (JP) 2007-04-11 CN disclosed
CN-1638773-A Pharmaceutical preparation containing aminobenzenesulfonic acid derivative as active ingredient MITSUBISHI PHARMA CORP (JP) 2005-07-13 CN disclosed
US-20050124632-A1 Remedies and/or preventives for diabetic ischemic heart diseases MITSUBISHI TANABE PHARMA CORPORATION (JP) 2005-06-09 US disclosed
CN-1533292-A Medicament inhititing sodium/calcium exchange system 三菱制药株式会社 2004-09-29 CN disclosed
CN-1496261-A Remedies and/or preventives for diabetic ischemic heart diseases 三菱制药株式会社 2004-05-12 CN disclosed
EP-1374868-A1 REMEDIES AND/OR PREVENTIVES FOR DIABETIC ISCHEMIC HEART DISEASES Mitsubishi Pharma Corporation (JP) 2004-01-02 EP disclosed
CN-1434724-A Remedies and/or preventives for nervous system disorders MITSUBISHI PHARMACEUTICALS INC (JP) 2003-08-06 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050124632-A1 Remedies and/or preventives for diabetic ischemic heart diseases SLC5A1, FABP3, IAPP HTR6 1339/4885MYC 3787/4885ADRB1 42/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.