Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ADCY1 | Q08828 | 7/20 | 0.33 |
| ▸ | ADCY8 | P40145 | 6/20 | 0.33 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5936335 | 0.73 | ALDH1A1 (0.42) | MAPTMAPK1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL6288849 | 0.73 | ALDH1A1 (0.42) | MAPTMAPK1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL28663639 | 0.68 | CYP11B1 (0.61) | MAPTMAPK1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL29541304 | 0.63 | CYP11B1 (0.55) | MAPTMAPK1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL28655422 | 0.63 | CYP11B1 (0.55) | MAPTMAPK1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL5905931 | 0.62 | CYP11B1 (0.50) | MAPTMAPK1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL6288319 | 0.61 | MGLL (0.35) | MAPTRAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL9845507 | 0.59 | CYP11B1 (0.61) | MAPTRAB9ASMN1; SMN2NPC1CYP11B1 | |
| SCHEMBL12424783 | 0.59 | CYP11B1 (0.40) | MAPTMAPK1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL14755710 | 0.58 | PSMB8 (0.53) | MAPTRAB9ASMN1; SMN2NPC1CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6956055-B2 | Substituted γ-lactone compounds as NMDA-antagonists | GRUNENTHAL GMBH (DE) | 2005-10-18 | — | — | US | disclosed |