Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 5/20 | 0.39 |
| ▸ | TUBB | P07437 | 5/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 5/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 5/20 | 0.39 |
| ▸ | TUBA4A | P68366 | 5/20 | 0.39 |
| ▸ | TUBB4B | P68371 | 5/20 | 0.39 |
| ▸ | TUBB3 | Q13509 | 5/20 | 0.39 |
| ▸ | TUBB2A | Q13885 | 5/20 | 0.39 |
| ▸ | TUBB8 | Q3ZCM7 | 5/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6288553 | 0.93 | TUBB4A (0.38) | SMN1; SMN2ALDH1A1HPGDKDM4ENPC1 | |
| SCHEMBL6288523 | 0.91 | TUBB4A (0.39) | SMN1; SMN2ALDH1A1HPGDKDM4ENPC1 | |
| SCHEMBL5619167 | 0.91 | TP53 (0.37) | SMN1; SMN2ALDH1A1HPGDKDM4ENPC1 | |
| SCHEMBL5619722 | 0.91 | TUBB4A (0.39) | SMN1; SMN2ALDH1A1HPGDKDM4ENPC1 | |
| SCHEMBL6288529 | 0.91 | TUBB4A (0.43) | SMN1; SMN2ALDH1A1HPGDKDM4ENPC1 | |
| SCHEMBL6287012 | 0.91 | POLB (0.38) | LMNATUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL6291762 | 0.88 | CRHR1 (0.42) | HPGDHSD17B10ADORA3TUBB1TSHR | |
| SCHEMBL6291396 | 0.87 | TUBB4A (0.38) | LMNATUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL8361772 | 0.87 | TUBB4A (0.36) | SMN1; SMN2ALDH1A1HPGDKDM4ENPC1 | |
| SCHEMBL6286598 | 0.87 | ALDH1A1 (0.41) | SMN1; SMN2ALDH1A1HPGDKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6936609-B2 | Imidazotriazines for use as phosphodiesterase inhibitors | BAYER HEALTHCARE AG (DE) | 2005-08-30 | — | — | US | disclosed |
| US-20040249148-A1 | Imidazotriazines for use as phosphodiesterase inhibitors | BAYER HEALTHCARE AG (DE) | 2004-12-09 | — | — | US | disclosed |
| EP-1404677-A1 | IMIDAZOTRIAZINES FOR USE AS PHOSPHODIESTERASE INHIBITORS | Bayer HealthCare AG (DE) | 2004-04-07 | — | — | EP | disclosed |
| WO-2003000693-A1 | IMIDAZOTRIAZINES FOR USE AS PHOSPHODIESTERASE INHIBITORS | BAYER HEALTHCARE AG (DE) | 2003-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040249148-A1 | Imidazotriazines for use as phosphodiesterase inhibitors | PDE3A, PDE2A, PDE4A | SMN1; SMN2 553/4885ALDH1A1 1467/4885HPGD 324/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.