SCHEMBL6288673

SCHEMBL6288673

CC[C@H](NC(=O)[C@@H](N)CC(C)(F)F)C(=O)c1nc(-c2ccccc2)no1.O=C(O)N1CCOCC1

nearest known ligand 0.40

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HDAC4 P56524 7/20 0.40
HDAC6 Q9UBN7 4/20 0.40
CYP1A2 P05177 1/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2C9 P11712 1/20 0.39
NPC1 O15118 1/20 0.37
MAPT P10636 1/20 0.37
RAB9A P51151 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
DPP4 P27487 1/20 0.36
DPP7 Q9UHL4 1/20 0.36
WNT3A P56704 1/20 0.36
HDAC3 O15379 1/20 0.36
HDAC1 Q13547 1/20 0.36
HDAC7 Q8WUI4 1/20 0.36
HDAC2 Q92769 1/20 0.36
HDAC8 Q9BY41 1/20 0.36
HDAC5 Q9UQL6 1/20 0.36
NAMPT P43490 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3869252 0.90 KDM4E (0.41) HDAC4HDAC6HDAC1HDAC2HDAC8
SCHEMBL13937556 0.87 CTSS (0.45) HDAC4HDAC6CYP1A2CYP3A4CYP2C9
SCHEMBL5823094 0.85 WNT3A (0.40) HDAC4HDAC6CYP1A2CYP3A4CYP2C9
SCHEMBL6077337 0.82 CTSS (0.43) HDAC4HDAC6CYP1A2CYP3A4CYP2C9
SCHEMBL8360108 0.82 CTSS (0.43) HDAC4HDAC6CYP1A2CYP3A4CYP2C9
SCHEMBL8292288 0.79 CTSS (0.44) HDAC4HDAC6CYP1A2CYP3A4CYP2C9
SCHEMBL6077329 0.78 CTSS (0.41) HDAC4HDAC6CYP1A2CYP3A4CYP2C9
SCHEMBL8361671 0.78 CTSS (0.41) HDAC4HDAC6CYP1A2CYP3A4CYP2C9
SCHEMBL6288672 0.77 HDAC4 (0.34) HDAC4HDAC6WNT3A
SCHEMBL14563109 0.75 CTSS (0.48) CYP1A2CYP3A4CYP2C9NPC1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005040142-A9 NOVEL KETO-OXADIAZOLE DERIVATIVES AS CATHEPSIN INHIBITORS AVENTIS PHARMA INC (US) 2005-06-09 WO claimed