Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 7/20 | 0.54 |
| ▸ | AKR1C2 | P52895 | 6/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 10/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.51 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.51 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.51 |
| ▸ | ALB | P02768 | 1/20 | 0.51 |
| ▸ | ESR1 | P03372 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.51 |
| ▸ | RARB | P10826 | 1/20 | 0.51 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.51 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5881684 | 0.84 | AKR1C3 (0.73) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| SCHEMBL1749031 | 0.82 | MAPT (0.60) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| SCHEMBL9474798 | 0.81 | LMNA (0.59) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| SCHEMBL8403335 | 0.81 | GPR88 (0.59) | AKR1C3AKR1C2PTGS2PTGS1LMNA | |
| SCHEMBL14599721 | 0.81 | GPR88 (0.59) | AKR1C3AKR1C2PTGS2TSHRLMNA | |
| SCHEMBL7403967 | 0.81 | GPR88 (0.59) | AKR1C3AKR1C2PTGS2PTGS1LMNA | |
| SCHEMBL6288738 | 0.80 | PTGS1 (0.65) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| SCHEMBL23582865 | 0.79 | TSHR (0.51) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| SCHEMBL11595380 | 0.79 | POLB (0.51) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| SCHEMBL8463046 | 0.79 | AKR1C3 (0.51) | AKR1C3AKR1C2PTGS2PTGS1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6838584-B2 | Estrogen receptor modulators | MERCK & CO., INC. (US) | 2005-01-04 | — | — | US | disclosed |
| US-20040162304-A1 | Estrogen receptor modulators | MERCK & CO., INC. | 2004-08-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040162304-A1 | Estrogen receptor modulators | ESRRA, GPER1, ESRRB | AKR1C3 649/4885AKR1C2 380/4885PTGS2 586/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.