Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.47 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | TNF | P01375 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6944962 | 0.86 | L3MBTL1 (0.48) | L3MBTL1ALDH1A1TSHRMAPK1TDP1 | |
| SCHEMBL29016707 | 0.84 | CA1 (0.48) | CA1CA2PARP10PARP1PARP2 | |
| SCHEMBL28140713 | 0.84 | AKR1C3 (0.54) | CA1CA2PARP10PARP1PARP2 | |
| SCHEMBL4459742 | 0.83 | TNF (0.52) | CA1CA2PARP10PARP1PARP2 | |
| SCHEMBL28014055 | 0.83 | CA1 (0.47) | CA1CA2PARP10PARP1PARP2 | |
| SCHEMBL21959089 | 0.81 | EPHX1 (0.57) | CA1CA2PARP10PARP1PARP2 | |
| SCHEMBL11080163 | 0.80 | ALOX5 (0.47) | CA1CA2PARP10PARP1PARP2 | |
| SCHEMBL27495544 | 0.79 | MMP13 (0.53) | CA1CA2PARP10PARP1PARP2 | |
| SCHEMBL30610835 | 0.78 | ALOX5 (0.44) | CA1CA2PARP10PARP1PARP2 | |
| SCHEMBL2405258 | 0.78 | CA1 (0.42) | CA1CA2PARP10PARP1PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040034228-A1 | Processes for preparing 6-hydroxy-3,4-dihydroquinolinone, cilostazol and N-(4-methoxyphenyl)-3-chloropropionamide | MENDELOVICI MARIOARA (IL) | 2004-02-19 | — | — | US | claimed |
| US-6660773-B2 | Reacting anisidine with 3-chloropropionamide to form N-(4-methoxy phenyl)-3-chloropropionamide; intramolecular Friedel-Crafts cyclization with a Lewis acid; decomposition of salt; demethylation | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 2003-12-09 | — | — | US | claimed |
| US-20030176703-A1 | Processes for preparing 6-hydroxy-3,4-dihydroquinolinone, cilostazol and N-(4-methoxyphenyl)-3-chloropropionamide | MENDELOVICI MARIOARA (IL) | 2003-09-18 | — | — | US | claimed |
| US-20020137936-A1 | Processes for preparing 6-hydroxy-3,4-dihydroquinolinone, cilostazol and N-(4-methoxyphenyl)3-chloropropionamide | MENDELOVICI MARIOARA (IL) | 2002-09-26 | — | — | US | claimed |
| US-20020032333-A1 | Processes for preparing 6-hydroxy-3,4-dihydroquinolinone, cilostazol and N-(4-methoxyphenyl)-3-chloropropionamide | TEVA PHARMACEUTICAL USA, INC. | 2002-03-14 | — | — | US | claimed |
| WO-2001070697-A1 | PROCESSES FOR PREPARING 6-HYDROXY-3,4-DIHYDROQUINOLINONE, CILOSTAZOL AND N-(4-METHOXYPHENYL)-3-CHLOROPROPIONAMIDE | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2001-09-27 | — | — | WO | claimed |
| US-6967209-B2 | Processes for preparing 6-hydroxy-3,4-dihydroquinolinone, cilostazol and N-(4-methoxyphenyl)-3-chloropropionamide | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2005-11-22 | — | — | US | disclosed |
| US-6740758-B2 | REACTING P-ANISIDINE WITH 3-CHLOROPROPIONYL CHLORIDE IN PRESENCE OF SODIUM BICARBONATE AND TOLUENE AND CYCLIZING | TEVA PHARMACEUTICAL INDUSTRIES (IL) | 2004-05-25 | — | — | US | disclosed |
| US-6660773-B2 | Reacting anisidine with 3-chloropropionamide to form N-(4-methoxy phenyl)-3-chloropropionamide; intramolecular Friedel-Crafts cyclization with a Lewis acid; decomposition of salt; demethylation | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 2003-12-09 | — | — | US | disclosed |
| US-20030176703-A1 | Processes for preparing 6-hydroxy-3,4-dihydroquinolinone, cilostazol and N-(4-methoxyphenyl)-3-chloropropionamide | MENDELOVICI MARIOARA (IL) | 2003-09-18 | — | — | US | disclosed |
| US-6525201-B2 | Amidation of p-anisidine with 3-chloropropionyl chloride; cyclization and demtylation of n-(4-methoxyphenyl)-3-chloropropionamide; optimal base/solvent combinations | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 2003-02-25 | — | — | US | disclosed |
| US-20020137936-A1 | Processes for preparing 6-hydroxy-3,4-dihydroquinolinone, cilostazol and N-(4-methoxyphenyl)3-chloropropionamide | MENDELOVICI MARIOARA (IL) | 2002-09-26 | — | — | US | disclosed |
| US-20020032333-A1 | Processes for preparing 6-hydroxy-3,4-dihydroquinolinone, cilostazol and N-(4-methoxyphenyl)-3-chloropropionamide | TEVA PHARMACEUTICAL USA, INC. | 2002-03-14 | — | — | US | disclosed |
| WO-2001070697-A1 | PROCESSES FOR PREPARING 6-HYDROXY-3,4-DIHYDROQUINOLINONE, CILOSTAZOL AND N-(4-METHOXYPHENYL)-3-CHLOROPROPIONAMIDE | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2001-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040034228-A1 | Processes for preparing 6-hydroxy-3,4-dihydroquinolinone, cilostazol and N-(4-methoxyphenyl)-3-chloropropionamide | HRH2, HRH3, HRH4 | CA1 1480/4885CA2 1794/4885PARP10 3795/4885 |
| US-20030176703-A1 | Processes for preparing 6-hydroxy-3,4-dihydroquinolinone, cilostazol and N-(4-methoxyphenyl)-3-chloropropionamide | HRH2, HRH3, HRH4 | CA1 1480/4885CA2 1794/4885PARP10 3795/4885 |
| US-20020137936-A1 | Processes for preparing 6-hydroxy-3,4-dihydroquinolinone, cilostazol and N-(4-methoxyphenyl)3-chloropropionamide | HRH2, HRH3, PDE8B | CA1 2010/4885CA2 2048/4885PARP10 3775/4885 |
| US-20020032333-A1 | Processes for preparing 6-hydroxy-3,4-dihydroquinolinone, cilostazol and N-(4-methoxyphenyl)-3-chloropropionamide | HRH2, HRH3, HRH4 | CA1 1480/4885CA2 1794/4885PARP10 3795/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.