Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.46 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL628441 | 0.87 | FFAR1 (0.53) | FFAR1PLA2G10PLA2G2AFFAR4KDM4E | |
| SCHEMBL6624770 | 0.86 | SLC6A3 (0.46) | SLC6A3SLC6A4SLC6A2GAAALDH1A1 | |
| SCHEMBL628630 | 0.86 | LOXL2 (0.50) | SLC6A3SLC6A4SLC6A2GAAALDH1A1 | |
| SCHEMBL628498 | 0.86 | ALDH1A1 (0.43) | SLC6A3SLC6A4SLC6A2ALDH1A1TSHR | |
| SCHEMBL6625716 | 0.85 | SLC6A3 (0.43) | SLC6A3SLC6A4SLC6A2GAAALDH1A1 | |
| SCHEMBL630123 | 0.85 | SLC6A3 (0.43) | SLC6A3SLC6A4SLC6A2GAAALDH1A1 | |
| SCHEMBL6774395 | 0.85 | SLC6A3 (0.44) | SLC6A3SLC6A4SLC6A2GAAALDH1A1 | |
| SCHEMBL2267132 | 0.82 | SLC6A3 (0.51) | SLC6A3SLC6A4SLC6A2ALDH1A1TSHR | |
| SCHEMBL630057 | 0.82 | MEN1 (0.46) | SLC6A3SLC6A4SLC6A2GAAALDH1A1 | |
| SCHEMBL26109493 | 0.81 | SRD5A2 (0.56) | SRD5A2FFAR1SLC22A12GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0986384-B1 | INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES | UNIV PITTSBURGH (US) | 2012-02-22 | — | — | EP | disclosed |
| EP-0986384-B1 | INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES | UNIV PITTSBURGH (US) | 2012-02-22 | — | — | EP | disclosed |
| US-6310095-B1 | INHIBITING OR TREATING CANCER, TREATING INTIMAL HYPERPLASIA ASSOCIATED WITH RESTENOSIS AND ATHEROSCLEROSIS, INHIBITING POST-TRANSLATIONAL MODIFICATION OF ONCOGENIC RAS PROTEIN BY PROTEIN FARNESYLTRANSFERASE AND/OR GERANYLGERANYLTRANSFERASE | UNIVERSITY OF PITTSBURGH | 2001-10-30 | — | — | US | disclosed |