Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10350661 | 0.84 | ALDH1A1 (0.52) | ALDH1A1HPGDMAPTNPC1RAB9A | |
| Bromide SCHEMBL6289057 | 0.82 | HDAC3 (0.50) | ALDH1A1MAPTNPC1RAB9AHDAC1 | |
| Bromide SCHEMBL6289517 | 0.80 | KMT2A (0.49) | ALDH1A1HPGDMAPTNPC1RAB9A | |
| SCHEMBL25424836 | 0.78 | ALDH1A1 (0.64) | ALDH1A1HPGDMAPTNPC1RAB9A | |
| Butane SCHEMBL11690769 | 0.77 | MAPT (0.57) | ALDH1A1HPGDMAPTNPC1RAB9A | |
| Bromide SCHEMBL394250 | 0.76 | KMT2A (0.54) | ALDH1A1HPGDMAPTNPC1RAB9A | |
| SCHEMBL303244 | 0.76 | ALDH1A1 (0.61) | ALDH1A1HPGDMAPTNPC1RAB9A | |
| SCHEMBL22367578 | 0.76 | ALDH1A1 (0.61) | ALDH1A1HPGDMAPTNPC1RAB9A | |
| Bromide SCHEMBL6289063 | 0.75 | MAPT (0.39) | ALDH1A1HPGDMAPTMEN1KMT2A | |
| SCHEMBL8756237 | 0.75 | GSK3B (0.57) | ALDH1A1HPGDNPC1RAB9AHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6900250-B2 | Polymerizable composition | TOYO INK MFG. CO., LTD. (JP) | 2005-05-31 | — | — | US | disclosed |
| US-20030212162-A1 | Photopolymerization using photoinitiators | TOYO INK MFG. CO., LTD. (JP) | 2003-11-13 | — | — | US | disclosed |